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作 者:于海明[1] 杨俊兰[1] 李莹[1] 焦顺昌[1]
出 处:《细胞与分子免疫学杂志》2015年第2期239-243,247,共6页Chinese Journal of Cellular and Molecular Immunology
基 金:吴阶平医学基金(320.6752.1230)
摘 要:目的分析胸腺基质淋巴细胞生成素(TSLP)表达对早期乳腺癌术后患者的预后预测价值,以及与辅助化疗远期疗效的关系。方法回顾性收集2000-01-01/2002-12-31期间在解放军总医院接受手术的130例Ⅰ-Ⅲ期乳腺癌患者的临床资料及石蜡切片,用免疫组织化学法检测乳腺癌原发灶TSLP的表达。用类流式组织细胞定量分析仪(FACS-like tissue cytometer analysis system)对免疫组织化学染色切片行计算机全切片扫描,并用Histo Quest软件对肿瘤区域阳性信号进行半定量分析。分析TSLP在乳腺癌原发灶的表达情况与乳腺癌预后的关联性以及与临床病理特征的相关性,还分析了TSLP表达与辅助化疗远期疗效的相关性。结果在COX多因素生存分析中,间质TSLP阳性细胞百分比是无病生存(DFS)的独立保护性预后因素。在接受过辅助化疗患者的COX多因素分析中,间质TSLP阳性细胞百分比是DFS、总生存(OS)的独立保护性预后因素。在TSLP间质阳性细胞百分比较高(≥39.14%)患者的LOG-RANK单因素生存分析中,接受辅助化疗的患者的OS较无辅助化疗组患者OS显著延长。结论乳腺癌原发灶间质细胞TSLP表达强度与预后及辅助化疗疗效相关。Objective To evaluate the prognostic value of thymic stromal lymphopoietin (TSLP) expression in early-stage postoperative breast cancer patients and its relationship with long-term efficacy of adjuvant chemotherapy. Methods Paraffin sections and clinical data were retrospectively collected from 130 stage Ⅰ -Ⅲ breast cancer patients who had underwent surgery at the Chinese PLA General Hospital from January 1st, 2000 to December 31st, 2002. Immunohistochemistry was used to assess TSLP expression in primary lesions of breast cancer. Sections were scanned in a FACS-like tissue cytometry analysis system, and digital images of the tumor area were semi-quantitatively analyzed using HistoQuest analysis software to evaluate the associations of TSLP expression with the prognosis and clinicopathologic features. Results Multivariate Cox survival analysis showed that the interstitial TSLP positive rate was an independent prognostic factor for disease-free survival (DFS). in patients who received adjuvant chemotherapy, the interstitial rSLP positive rate was an independent prognostic factor for DFS and overall survival (OS). Univariate LOG-RANK showed that, in patients with higher interstitial TSLP positive rates (≥39.14% ), OS of the patients who received adjuvant chemotherapy was significantly longer than that of those who did not (P=0.008). Conclusion Interstitial TSLP expression in breast tumors is associated with the prognosis and efficacy of adjuvant chemotherapy.
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