血管性认知功能障碍分数低频振幅的 fMRI 研究  

Fractional amplitude of low-frequency fluctuation in patients with VCI based on functional MRI

作　　者：陈雪[1] 丁伟娜[1] 孙雅文[1] 周滟[1] 庄治国[1] 徐群[2] 唐辉[1] 许建荣[1] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科,上海200127 [2]上海交通大学医学院附属仁济医院神经科,上海200127

出　　处：《实用放射学杂志》2015年第2期177-181,共5页Journal of Practical Radiology

基　　金：国家自然基金（81171325;81201172）.

摘　　要：目的：利用基于分数低频振幅算法（fALFF）的功能磁共振技术探讨血管性认知障碍（VCI）患者静息态脑功能改变。方法收集无认知损害（NCI）、血管性认知障碍无痴呆（VCIND）和血管性痴呆（VD）患者共49例,比较各组间全脑 fALFF 的差异,并与 MoCA 做相关分析。结果静息态下,VCIND 组较 NCI 组左侧眶额回 fALFF 减低,而双侧额中回增高；VD 组较 VCIND 组左侧壳核、额中回及顶下小叶、右侧额中回/中央前回 fALFF 减低；VD 组较 NCI 组左侧眶额回、壳核及颞横回、右侧丘脑 fALFF 减低。VCI 组左侧壳核及丘脑的 fALFF 值与 MoCA 评分呈正相关。结论VCI 组静息态脑功能有改变,左侧壳核及丘脑的 fALFF降低与认知功能损害相关。Objective To investigate the baseline brain activity in patients with vascular cognitive impairment （VCI）by fractional amplitude of low-frequency fluctuation （fALFF）based on resting-state functional MRI （fMRI）.Methods The whole brain fALFF values of 49 patients with no cognition impairment（NCI）,vascular cognitive impairment with no dementia（VCIND）and vascular de-mentia（VD）were collected and compared.The correlations between the whole brain fALFF values of VCI patients with scores of MoCA were assessed.Results Compared with NCI group,the fALFF values decreased in the left orbitofrontal cortex but increased in bilateral middle frontal gyrus of VCIND group.fALFF values in the left putamen,left middle frontal gyrus,left inferior parietal lobule and right middle frontal gyrus/precentral gyrus of VD group were lower than those of VCIND group.The VD patients showed lower fALFF values in left orbitofrontal cortex,leftputamen,left transverse temporal gyrus and right thalamus than those of NCI patients.In addition,the fALFF values in the left putamen and thalamus of VCI patients had significantly positive correlation with scores of MoCA.Conclusion fALFF values of the VCI patients had significantly changed.And the decreased fALFF values in left putamen and thalamus may associate with cognitive disfunction.

关 键 词：血管性认知障碍 静息态功能磁共振成像 分数低频振幅 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]