淡水鱼摄取对女性乳腺癌发病风险影响研究  

Relationship between freshwater fish intake and female breast cancer

作　　者：戴立玲[1] 高长明[1] 丁建华[1] 李苏平[1] 刘燕婷[1] 唐金海[2] Kazuo Tajima 

机构地区：[1]江苏省肿瘤防治研究所流行病室,江苏南京210009 [2]江苏省肿瘤防治研究所普外科,江苏南京210009 [3]日本三重大学医学研究所公共卫生和职业医学部

出　　处：《中华肿瘤防治杂志》2015年第5期325-329,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：日本文部科技运动省国际科学研究癌症特别研究项目(11137311);江苏省科技厅社会发展重大项目(BS2006006)

摘　　要：目的 研究5种淡水鱼（青鱼、鲫鱼、黄鳝、鳊鱼和鲢鱼）摄取对女性乳腺癌发病风险的影响.方法 采用病例-对照研究方法,于2004-06-01-2007-12-31在江苏省泰兴、无锡、淮安和金坛市,采用包括83个饮食项目的定量问卷表调查669例乳腺癌患者和682名健康对照的饮食状况.采用非条件Logistic回归方法分析乳腺癌的发病风险（OR）及其95％可信限（95％CI）.结果 5种鱼类合计分析显示,淡水鱼摄取降低了乳腺癌的发病风险,但无剂量-反应关系.不同种类淡水鱼分析显示,青鱼和鲢鱼的摄取量与乳腺癌的发病风险负相关,与不吃青鱼组相比,月摄取量≥500 g组的调整OR为0.54,95％CI：0.33～0.92,P＜0.001;与不吃鲢鱼组相比,月摄取量≥1 000 g组的调整OR为0.19,95％CI：0.11～0.33,P＜0.001.黄鳝的摄取量也与乳腺癌的发病风险负相关,P＜0.001;但其最高摄取量组（≥500 g/月）的调整OR值差异无统计学意义.而鲫鱼的摄取量与乳腺癌的发病风险正相关,与不吃鲫鱼组相比,月摄取量≥1 000 g组的调整OR为6.09,95％CI：3.04～12.19,P＜0.001.鳊鱼的月摄取量与乳腺癌的发病风险无相关性,但月摄取量在1～499 g和500～999 g组的OR显著降低,而月摄取量≥1 000 g组的OR明显升高.结论 淡水鱼摄取影响乳腺癌的发病风险,不同种类的淡水鱼及其摄取量对乳腺癌发病风险的影响有所不同.OBJECTIVE To investigate the association between the intake of 5 species of freshwater fish （black carp,finless eel,bream,crucian carp） and silver carp and the risk of breast cancer in Chinese women. METHODS A case- control study was conducted with 669 cases and 682 population-based controls in Jiangsu Province of China. A structured questionnaire was used to elicit detailed information. Unconditional logistic regression analysis was performed to calculate odds ratios （ORs） and 95% confidence intervals （CIs）. RESULTS Total freshwater fish intake decreased the adjusted OR of breast cancer,but no dose-response relation. Analyses by freshwater fish species showed that consumption of fin- less eel and silver carp were inversely related to breast cancer risk, with an adjusted-OR for the highest intake category of black camp（≥500 g/month） of 0.54 （95GCI：0. 33-0. 92; P〈0. 001） and for the highest intake category of silver carp （≥1 000 g/month） of 0.19 （95%CI：0.11-0.33; P〈0. 001）. Reduced risk was also related to high consumption of finless eel （P〈0. 001）,but the adjusted-OR of the highest intake category （≥500 g/month） was not statistically significant. In contrast,consumption of crucian carp was positively related to breast cancer risk, with an adjusted OR for the highest intake category （≥1 000 g/month） of 6.09 （95%CI：3.04-12.19; P〈0. 001）. With regard to intake of bream, compared with the never intake of bream, the second and the third intake categories all had a significant decreased OR, but OR of the highest intake category （≥1 000 g/month） showed a clear increase. CONCLUSION The findings of this study suggest that intakes of freshwater fish may modify risk of breast cancer,and that different species of fish and their con- sumption could have a different action on breast cancer risk.

关 键 词：乳腺肿瘤 发病风险 淡水鱼 消费量 

分 类 号：R737.9[医药卫生—肿瘤]