肠道微生物在人类疾病中的作用  

Role of Gut Microbiota in Human Diseases

作　　者：廖博雅 王莎莎 张军东 于鸿晶[2,3] 

机构地区：[1]华东理工大学药学院,200237 [2]上海信谊药厂有限公司 [3]上海交通大学药学院

出　　处：《胃肠病学》2015年第2期126-128,共3页Chinese Journal of Gastroenterology

基　　金：上海市科委产学研医合作项目(11DZ1920904)资助

摘　　要：人类肠道中栖息着上百种微生物,行使着消化、营养、免疫、共生等重要生理功能,大量研究表明肠道微生物对肠道功能具有重要影响。利用系统生物学方法可从整体上研究人体肠道系统,确认肠道微生物与免疫、代谢之间的关联。本文就肠道微生物与人类疾病间的相互作用,包括免疫缺陷相关疾病、腹腔疾病、环境性肠病、肠道细菌相关的代谢疾病和肥胖,以及致病机制和研究模型作一综述。Hundreds of microbial species live in human gut and host different physiologic functions,such as digestion,nutrition,immunity,and coexistence. Numerous studies have shown that gut microbiota plays an important role in gut function. Systematic biologic methods provide essential tools for studying the gut system as a whole and identifying the key interaction between gut microbiota,immunity,and metabolism. This article reviewed the interaction,mechanism,and models of study between gut microbiota and human diseases including immunodeficiency-associated disease,celiac disease,environmental enteropathy,gut microbiota-associated metabolic disease and obesity.

关 键 词：免疫 肠道微生物 代谢 肠疾病 

分 类 号：R574[医药卫生—消化系统]