Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达及意义  

Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones

作　　者：孔丽[1] 王炳超[1] 袁荣涛[1] 贾暮云[1] 王科[1] 

机构地区：[1]青岛大学附属医院口腔颌面外科,山东青岛266003

出　　处：《上海口腔医学》2015年第1期89-93,共5页Shanghai Journal of Stomatology

基　　金：青岛市公共领域科技支撑计划项目[11-2-3-1-(20)-nsh]~~

摘　　要：目的:研究Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达,探讨其发挥的调控作用。方法:收集颌骨牙源性角化囊性瘤新鲜标本及同一患者的正常口腔黏膜,提取RNA,基因芯片检测Wnt信号通路的相关基因,进行生物信息学分析。结果:颌骨牙源性角化囊性瘤与正常口腔黏膜相比,在Wnt信号通路相关基因中发现5个共同差异表达基因,其中CAMK2A下调,FZD3、MAPK10、PRKX、WNT5a上调。结论:牙源性角化囊性瘤中存在Wnt信号通路基因的异常表达,Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中发挥一定的调控作用。PURPOSE： To study the role of genes of Wnt signaling pathway in keratocystic odontogenic tumor（KCOT） of the jaw bones. METHODS： Fresh specimens of KCOT and the same patient ＇s normal oral mucosa were obtained. Then RNA was extracted. Gene chip was used to detect the genes of Wnt signaling pathway. RESULTS： Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2 A down-regulated, FZD3,MAPK10, PRKX and WNT5 a up-regulated. CONCLUSIONS： There are abnormal expressions of genes of Wnt pathway in KCOT. Genes of Wnt pathway plays certain roles in KCOT.

关 键 词：牙源性角化囊性瘤 WNT信号通路 寡链核苷酸分析 

分 类 号：R739.8[医药卫生—肿瘤]