基于稀疏重建的EMD脉搏色素密度谱的处理  

A Processing Method of Pulse Dye Densitogram Based on Sparse Rebuild and Empirical Mode Decomposition

作　　者：张晓枫[1,2] 刘光达[1] 陈勇[1] 周润东[1] 查雨彤 

机构地区：[1]吉林大学仪器科学与电气工程学院,长春130061 [2]长春理工大学生命科学技术学院,长春130022

出　　处：《科学技术与工程》2015年第5期36-40,共5页Science Technology and Engineering

基　　金：国家重大科学仪器设备开发专项的子题(120111222867002);国家自然科学基金项目(21207047);高等学校博士学科点专项科研基金课题(20120061110092);吉林省科技发展计划重点项目(20120328)资助

摘　　要：基于脉搏血氧计的吲哚青绿(Indocyanine green,ICG)脉搏密度谱测量方法是无创肝储备功能的主要检测原理。近红外脉搏色素密度谱的提取及处理直接影响着肝储备功能检测参数的计算精度。针对自行研发的脉搏色素密度谱采集装置采集的近红外光谱信号的光谱噪声及干扰问题,采用了结合稀疏二进制重建的经验模态分解法对ICG密度谱进行处理。将处理后提取的ICG密度谱进行分析计算,得到的ICG血浆消失率值与报告值相比较,其最大相对误差为5.1%;而平均相对误差为3.2%。实验结果表明,结合自适应稀疏二进制重构的经验模态分解方法对消除色素光谱的噪声是有效的,有效地提高了脉搏色素密度谱的测量精度,从而提高肝储备功能检测参数的精度。为近红外脉搏色素光谱提取优化提供了一种新方法,为抗干扰的无创肝储备功能的检测提供理论依据和实用方法。The measurement method of indocyanine green concentration spectrum based on the pulse oximetry is the main detection principle of the liver reserve function. The accuracy of liver detection parameters is directly influenced by extraction and processing of pulse dye densitogram of near infrared spectrum. The paper focus on the problem of the following spectrum noisy and interference from the extraction the dye intensity signal by self-developed pulse spectrum signal acquiring device,so a method of joint empirical mode decomposition（ EMD） and sparse rebuild for processing the pulse dye densitogram is developed. From the result comparison of the value of ICG plasma disappear rate between this method to hospital reports,the maximal relative error is 5. 1% and the average relative error is 3. 2%. The results show that,the sparse rebuild EMD is a useful method to eliminate noise of pulse dye densitogram,which makes the final pulse dye desitogram more representative and accurate. Hence,the paper provides a new method for optimized extraction of near-infrared pulse dye spectrum which can effectively improving the prediction accuracy of hepatic reserve function detection parameters. And a theoretical basis and practical measurement method of noninvasive liver reserve function with anti-interference detection is provided.

关 键 词：脉搏色素光谱 经验模态分解 吲哚青绿 肝血流参数 稀疏重建 

分 类 号：R318.11[医药卫生—生物医学工程]