激素敏感性脂肪酶HSL对生殖系统的整合调控  

The Integration and Regulation of Hormone-Sensitive Lipase in Reproductive System

作　　者：王威仪[1] 徐国恒[1] 

机构地区：[1]北京大学基础医学院生理学与病理生理学系,北京100191

出　　处：《生理科学进展》2015年第1期1-5,共5页Progress in Physiological Sciences

基　　金：国家自然基金(30890042;81070114);国家重点基础研究发展计划(2009CB41603;2012CB517505)资助课题

摘　　要：激素敏感性脂肪酶被认为是经典的脂肪分解限速酶,可特异水解甘油三酯,受儿茶酚胺等激素调控。近年来研究表明:HSL作用底物不仅有甘油三酯,还包括甘油二酯、甘油一酯、胆固醇酯等。然而,脂肪酶在生殖系统的功能并不清楚,基因敲除小鼠为证实HSL广泛存在于生殖系统提供良好模型,提示其可能在生殖系统生理及病理生理过程发挥重要调节作用,本文将着重介绍生殖系统中HSL基因与蛋白质结构并总结其在生殖系统的功能。Hormone-sensitive lipase（ HSL） has long been considered as a classical rate-limiting enzyme during lipolysis since it was first described in 1960 s. HSL is regulated mainly by catecholamine,including adrenalin. Studies in recent years indicated that the substrates for HSL are not only triglycerides,but also diacylglycerol with the catalytic activity is ten times that of triglycerides,glycerol esters and cholesterol esters,which overthrow the opinion that HSL is specific to triglyceride. The scientists have generated HSL gene knockout mice and confirmed HSL is widely located in the reproductive system,which indicates that HSL may play an important role in the regulation of physiological and pathophysiological process in the reproductive system. Here,we will focus on the features of the HSL gene,mRNA and its protein,and summarize the HSL functions in the reproductive system.

关 键 词：激素敏感性脂肪酶 生殖系统 睾丸 脂肪组织 脂肪分解 

分 类 号：Q591[生物学—生物化学]