高膳食纤维低血糖生成指数粗杂粮食品对糖尿病前期人群肠道菌群的干预作用研究  

The Study on the Intervention Effect of High Dietary Fiber and Low GI Coarse Grain Food for Pre-diabetic Patients' Gut Microbiota

作　　者：安阳[1] 张文青[2] 郭丽娜[1] 刘娟[1] 郝丹丹[1] 

机构地区：[1]山西医科大学公共卫生学院,山西太原030001 [2]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2015年第3期163-166,共4页Proceeding of Clinical Medicine

基　　金：现代农业产业技术体系建设专项资金资助(项目编号:CARS-08-D-2-12)

摘　　要：目的:分析高膳食纤维低血糖生成指数(GI)粗杂粮食品对糖尿病前期人群肠道菌群的干预效果。方法:从社区筛选出糖尿病前期者100例,随机分为干预组(50例)和对照组(50例)。对干预组采用可溶性膳食纤维和低GI粗杂粮营养配方食品,辅以营养教育、运动、饮食和心理等医学营养干预措施干预2个月;对照组不采取任何措施。应用荧光定量PCR法比较两组人群干预前后肠道菌群中乳酸杆菌、双歧杆菌、大肠杆菌数量的变化。结果:干预后,干预组人群肠道中的双歧杆菌、乳酸杆菌数明显升高(P<0.05),大肠杆菌数明显下降(P<0.05);对照组的观察指标较前变化不明显(P>0.05)。结论:高膳食纤维低GI粗杂粮食品能够调整糖尿病前期人群的肠道菌群结构,扶持有益肠道菌,抑制条件致病菌,恢复肠道微生态,从而阻止或延缓慢性代谢疾病的发生发展。Objective： To analyze the intervention effect of high dietary fiber and low GI coarse grain food for pre- diabetic patients＇ gut microbiota. Methods： 100 pre- diabetic patients were selected from the community,and randomly divided into intervention group and control group. There were 50 people in each group. The intervention group was intervened for two months with nutrition formulation food（ soluble dietary fiber and low- GI coarse grain）,combined with nutrition education,exercise intervention,diet intervention,psychological interventions and other medical nutrition intervention measures. The control group had no measures. Comparing the difference in the two groups,gut microbiota（ lactobacillus,bifidobacteria,E. coli） using fluorogenic quantitative PCR before and after the intervention. Results： After the intervention,the intervention group＇ s lactobacillus and bifidobacteria increased obviously（ P 〈0. 05）,and E. coli declined obviously（ P〈 0. 05）. The control group＇ s indicators had no change（ P 〉0. 05）. Conclusion： The high dietary fiber and low GI coarse grain food can adjust the structure of gut microbiota of pre- diabetic patients,support beneficial intestinal bacteria,suppress conditioned pathogen,restore intestinal microflora,and prevent or delay the occurrence and development of chronic metabolic disease.

关 键 词：糖尿病前期 肠道菌群 膳食纤维 低血糖生成指数粗杂粮 

分 类 号：R587.1[医药卫生—内分泌]