焦虑症患者认知电位P300及感觉门控P50特点  

Cognitive P300 and P50 sensory gating characteristics of patients with anxiety disorders

作　　者：谢志兵 梁美玲 

机构地区：[1]珠海市慢性病防治中心精神卫生科,519000

出　　处：《四川精神卫生》2015年第1期25-27,共3页Sichuan Mental Health

摘　　要：目的探讨焦虑症患者的认知电位P300及感觉门控P50的特点。方法选取2014年1月-10月在珠海市慢性病防治中心心理科门诊就诊的符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)焦虑症诊断标准的患者67例。采用汉密尔顿焦虑量表14项版(HAMA-14)评定病情严重程度,并进行认知电位P300及感觉门控P50检测,与40名正常人(对照组)进行比较。结果 1焦虑症组P300潜伏期较对照组长[(378.26±53.47)ms vs.(332.65±37.78)ms,(P<0.01)];2焦虑症组P50抑制比(S2/S1波幅比值)高于对照组[(89±41)%vs.(55±20)%,P<0.01]。结论焦虑症患者P300潜伏期较正常人长,认知功能减退;听感觉门控电位P50抑制存在缺损,不能有效滤过无关信息。P300及P50检测可能成为筛查焦虑症患者早期认知功能损害的辅助指标。Objective To explore the characteristics of cognitive potential P300 and sensory gating P50 in patients with anxiety.Methods From 2014 January to October,a total of 67 patients met the diagnosis of anxiety disorder of CCMD-3 in Zhuhai chronic disease prevention and control center of psychological outpatient clinic were selected. Hamilton Anxiety Rating Scale-14 items( HAMA-14) was used to assess the disease severity. And cognitive potentials P300 and Sensory gating potential P50 detection were compared with 40 normal persons( control group). Results 1The P300 latency of the anxiety group was longer than the control group[( 378. 26 ± 53. 47) ms vs.( 332. 65 ± 37. 78) ms,( P < 0. 01) ]. 2The P50 suppression ratio( S2 /S1 amplitude ratio) of the anxiety group was higher than that of the control group [( 89 ± 41) % vs.( 55 ± 20) %,P < 0. 01]. Conclusion Compared with the normal,patients with anxiety disorder were significantly prolonged the latency of P300,significantly impaired cognitive function. Auditory sensory gating potential P50 inhibitory existing defects,and can not effectively filtering irrelevant information. Detection of P300 and P50 could be screening patients with anxiety disorder auxiliary index of early cognitive impairment.

关 键 词：焦虑症 认知电位P300 感觉门控电位P50 

分 类 号：R749.4[医药卫生—神经病学与精神病学]