舍曲林合并低剂量氨磺必利治疗重度抑郁症的对照研究  

Comparative study of sertraline augmented with small dose amisulpride in the treatment of major depressive disorder

作　　者：王冬梅[1] 陈玉辉[1] 

机构地区：[1]天津市安宁医院,300000

出　　处：《四川精神卫生》2015年第1期31-33,共3页Sichuan Mental Health

摘　　要：目的观察舍曲林合并低剂量氨磺必利对重度抑郁症的临床疗效。方法采用随机数字表法将符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)诊断标准的58例重度抑郁症患者分为研究组(舍曲林合并低剂量氨磺必利)和对照组(单用舍曲林),共观察12周,于治疗前及治疗后2、4、8、12周末采用汉密尔顿抑郁量表(HRSD)和副反应量表(TESS)评定临床疗效及不良反应。结果治疗12周后,研究组和对照组有效率分别为89.28%和60.00%,差异有统计学意义(P<0.05)。治疗后2、4、8、12周末两组HRSD评分均较治疗前低,差异有统计学意义(P<0.05)。在治疗后第2、4、8、12周末,研究组HRSD评分较对照组低,差异有统计学意义(P<0.05)。两组副作用均较小。结论舍曲林合并低剂量氨磺必利对重度抑郁症的疗效和安全性优于单用舍曲林,且起效迅速。Objective To investigate the efficacy of sertraline augmented with small dose amisulpride in the treatment of major depression. Methods A total of 58 patients were randomly divided into study group treated with sertraline combined with amisulpride and control group treated with sertraline for 12 weeks. The efficacy and side effects were evaluated with Hamilton Depression Rating Scale( HRSD) and Treatment Emergent Symptom Scale( TESS). Results After treatment for 12 months,the effective rates of two groups were 89. 28% and 60. 0%,respectively,there was significant difference( P < 0. 05). Scores of HRSD in two groups both decreased significantly after the treatment( P < 0. 05). Scores of HRSD in study group were significantly lower than that in control group at the 8thand 12thweekend( P < 0. 05). Side effects in the two groups were mild. Conclusion Sertraline augmented with small dose amisulpride has better effect than reboxetine monotherapy in the treatment of major depression with satisfactory tolerability.

关 键 词：舍曲林 氨磺必利 重度抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]