CXCR4、VEGF-C和MMP-9在胃癌淋巴结转移中的作用及意义  

Correlation of CXCR4,VEGF,MMP-9 expression with lymphatic metastasis in gastric cancer

作　　者：李利义[1] 罗越[1] 刘海斌[1] 韩绍伟[1] 王飞海[1] 郑志强[1] 

机构地区：[1]温州医科大学附属第二医院胃肠外科

出　　处：《浙江医学》2015年第2期107-110,共4页Zhejiang Medical Journal

基　　金：温州市科技计划基金(Y20090061)

摘　　要：目的探讨趋化性细胞受体因子4（CXCR4）、血管内皮生长因子-C（VEGF—C）和基质金属蛋白酶-9（MMP-9）在胃癌淋巴结转移中的作用及意义。方法应用免疫组化法检测76例人胃癌组织中CXCR4、VEGF—C和MMP-9的表达水平．并分析其与胃癌淋巴结转移的关系。结果CXCR4、VEGF—C或MMP-9任一指标表达水平与胃癌淋巴结转移均有显著关系（均，P〈0．01）．且这3项指标两两相关，CXCR4NEGF—C联合阳性表达的患者淋巴结转移率为848％（28／33）。高于仅1项指标阳性表达（11／22，500％）及两者联合阴性表达（7／21，333％）的患者，差异有统计学意义（均P〈001）；VEGF—C／MMP-9联合阳性表达的患者淋巴结转移率为80O％（32／40），高于仅1项指标阳性表达（9／19，47.4％）及两者联合阴性表达（5／17，29．4％）的患者，差异均有统计学意义（P〈0．05或0．01）；CXCR4／MMP-9联合阳性表达的患者淋巴结转移率为83．3％（30／36），高于仅1项指标阳性表达（11／22，500％）及两者联合阴性表达（5／18，27.8％）的患者，差异均具有统计学意义（均P〈001）。3项指标共同表达的患者淋巴结转移率高达90．O％。结论CXCR4、VEGF—C和MMP-9在胃癌组织中的表达与淋巴结转移关系密切，如果3项指标均为阳性者淋巴结转移的可能性最大。Objective To investigated the association of CXCR4, VEGF-C, MMP-9 expression with lymphatic metas- tasis in gastric cancer. Methods The expressions of CXCR4, VEGF-C and MMP-9 were detected by immuohistochemistry in 76 samples of gastric cancer. The relationship between these markers and lymph node metastasis of gastric cancer was analyzed. Results The expression of CXCR4,VEGF-C and MMP-9 was significantly associated with lymph node metastasis in gastric cancer（P〈0.01）. The expressions of three proteins were significant correlated with each other. Rate of lymph node metastasis in patients with expression of both CXCR4 and VEGF-C was 84.5%（28/33）, which was significantly higher than that in patients with single protein expression （11/22, 50.0%） or in those with negative expression（7/21, 33.3%）. Similarly, the rate in patients with both VEGF-C and MMP-9 expression was 80.0% （32/40）, which was higher than that in patients with single protein positive expression （9/19, 47.4%）, or in those with negative expression （5/17, 29.4%）. The rate in patients with both CXCR4 and MMP-9 expression was 83.3% （30/36）, which was higher than that in patients with single protein positive expression （11/22, 50.0%）, or in those with negative expression （5/18, 27.8%）. The differences were all found to be statistically significant （P〈0.01）. The rate of lymph node metastasis in patients with expression of all three proteins was 90.0%（27/30）. Conclusion The expression of CXCR4, VEGF-C and MMP-9 is closely correlated with lymph node metastasis in gastric cancer, patients with positive expression of three markers are most likely to have lymph node metastasis.

关 键 词：趋化性细胞受体因子4 血管内皮生长因子-C质金属蛋白酶-9 胃癌 淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]