中枢神经细胞瘤18例诊断与治疗回顾性分析  

Diagnosis and treatment of central neurocytoma: a retrospective analysis of 18 cases

作　　者：陶超[1] 徐佳[1] 程刚[1] 耿晓增[1] 陈云祥[1] 

机构地区：[1]南京医科大学第一附属医院神经外科,江苏南京210029

出　　处：《国际神经病学神经外科学杂志》2014年第6期517-521,共5页Journal of International Neurology and Neurosurgery

基　　金：江苏省科教兴卫工程医学重点学科(No.XK201117)

摘　　要：目的 回顾性分析中枢神经细胞瘤患者的临床特点和治疗效果,探索最佳的治疗策略。方法 2006年6月至2013年4月间我院共收治中枢神经细胞瘤患者18例。16例患者肿瘤位于侧脑室,其中5例经纵裂-胼胝体-侧脑室入路手术,11例经大脑皮层-侧脑室入路手术。2例患者肿瘤位于第四脑室,经枕下正中入路手术。回顾和分析这些患者的临床、影像和病理特点。结果 13例实现肿瘤全切,5例次全切。1例患者术后死亡,1例术后4个月复发后放弃治疗,1例失访。15例患者随访14~96个月,平均37.9个月。随访期间均未见肿瘤复发或残余肿瘤进一步生长。结论 手术是治疗中枢神经细胞瘤的最佳选择,如未能实现肿瘤全切,术后需放疗。Objective To investigate the optimal therapeutic strategy by retrospectively reviewing the clinical characteristics and outcomes of patients with central neurocytoma（ CN）. Methods The clinical,imaging,and pathological characteristics of 18 consecutive patients with CN who were admitted to our hospital from June 2006 to April 2013 were respectively reviewed. Among 16 patients with CN located in the lateral ventricles,5 patients underwent operations via the transcallosal approach and 11 patients underwent operations via the transcortical approach. Two patients with CN located in the fourth ventricle underwent operations via the suboccipital approach.Results Total resection was achieved in 13 patients,and subtotal resection was performed in 5 patients. One patient died after surgery and one patient abandoned treatment due to recurrence at 4 months after surgery. One patient was lost to follow up and 15 patients were followed up for 37. 9 months（ range,14- 96 months）. There was no recurrence or further growth of the residual tumor during followup. Conclusions The study suggests that initial surgery is the optimal treatment choice for CN. The patients who do not achieve total resection need postoperative radiotherapy.

关 键 词：中枢神经细胞瘤 脑室内肿瘤 手术学 

分 类 号：R739.4[医药卫生—肿瘤]