血清胃泌素17水平与胃癌及癌前疾病的相关性研究  

The association between serum G17 and precancerous disease and gastric cancer

作　　者：陈莫耶[1] 徐倩[2] 孙丽萍[2] 孙明军[1] 

机构地区：[1]中国医科大学附属第一医院消化内科,辽宁沈阳110001 [2]中国医科大学附属第一医院肿瘤研究所暨普通外科研究所肿瘤病因与筛查研究室,辽宁省高校肿瘤病因与预防重点实验室,辽宁沈阳110001

出　　处：《胃肠病学和肝病学杂志》2015年第2期161-165,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨血清胃泌素17(G17)水平与胃癌及癌前疾病的相关性。方法纳入2011年-2012年于中国医科大学附属第一医院消化内科就诊患者1 336例,应用酶联免疫吸附测定法(ELISA)检测血清G17水平及幽门螺杆菌Ig G(H.pylori-Ig G)抗体滴度。结果在60岁以上、H.pylori-Ig G阴性、萎缩性胃炎(AG)组及胃癌(GC)组中,女性患者血清G17水平均显著高于男性患者(P<0.05)。在非AG组及异型增生(GD)组中,H.pylori阳性患者血清G17水平显著高于H.pylori阴性患者(P<0.05)。在所有患者中,与SG组相比,GC、胃黏膜糜烂(GE)和胃溃疡(GU)组血清G17水平显著升高(P<0.05);与浅表性胃炎伴糜烂(SG-IM)组相比,GD、GC、GE和GU组G17水平显著升高(P<0.05);与AG组相比,GC、GE和GU组G17水平显著升高(P<0.05)。在H.pylori阴性患者中,与SG组相比,GC组和GU组血清G17水平显著升高(P<0.05);与SG-IM组相比,AG、GC、GE和GU组G17水平显著升高(P<0.05);与GD组相比,GU组血清G17水平显著升高(P=0.007)。结论血清G17水平受患者性别及H.pylori感染等相关因素的影响,在从SG、SG-IM、AG、GD到GC的动态变化过程中呈逐渐升高的趋势,且GC患者较其他疾病明显升高。血清G17可能作为胃癌的生物标志物,有望成为胃癌筛查及早期诊断的一个重要观测指标。Objective To investigate the association between serum G17 levels and precancerous lesions and gastric cancer. Methods From 2011 to 2012,a total of 1 336 participants were selected and enrolled in this study. G17 and H. pylori-Ig G were measured with ELISA. Results The level of serum G17 in females was significantly higher than that in males in those ≥60 years,a negative status of H. pylori-Ig G,and in atrophic gastritis（ AG） and gastric cancer（ GC）individuals（ P 〈0. 05）. The level of serum G17 was higher in H. pylori seropositive individuals than in H. pylori-seronegative individuals with non-AG and gastric dysplasia（ GD）（ P〈0. 05）. In total samples,G17 was significantly higher in GC,gastric erosion（ GE） and gastric ulcer（ GU） groups than that in SG group（ P 〈0. 05）; compared with SGIM group,G17 was significantly higher in GD,GC,GE and GU groups（ P 〈0. 05）; G17 were significantly higher in GC,GE and GU groups than that in AG group（ P 〈0. 05）. In H. pylori seronegative individuals,the serum G17 were significantly higher in GC and GU than that in superficial gastritis（ SG）（ P 〈0. 05）; Compared with SG-GIM,the serum G17 were significantly higher in AG,GC,GE and GU groups（ P 〈0. 05）; Compared with GD,the serum G17 was higher in GU group（ P = 0. 007）. Conclusion The levels of serum G17 is influenced by the gender and the status of H. pylori infection,which is gradually raised in the gastric disease progression from SG,SG-IM,AG,GD to GC,especially for the patients with GC. As a biomarker of gastric cancer,it is expected to be an important indicator in screening of disease and early diagnosis.

关 键 词：胃泌素 萎缩性胃炎 胃癌 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]