Caspase-8在原发性干燥综合征唇腺组织中的表达  

Expression of Caspase-8 in labial glands of primary Sjogren's syndrome

作　　者：康媛媛[1] 孙富丽[1] 张英[1] 

机构地区：[1]中国医科大学口腔医学院综合急诊科,辽宁省口腔医学研究所口腔黏膜病学研究室,辽宁沈阳110002

出　　处：《口腔医学》2015年第2期89-92,共4页Stomatology

基　　金：辽宁省科学技术计划项目(2011225020);2013年院级青年科研启动基金(K101593-13-39)

摘　　要：目的探讨Caspase-8在原发性干燥综合征唇腺组织中的表达及意义,并分析它的表达与临床特征的相关性。方法采用免疫组化和Western blotting的方法检测55例原发性干燥综合征患者和15例健康者唇腺组织中Caspase-8蛋白的表达,测量吸光度值,采用SPSS 14.0软件包对两组结果进行统计学分析。结果原发性干燥综合征唇腺组织中Caspase-8在蛋白水平上有表达,与健康对照组相比明显升高(P<0.05),并与疾病的病程呈正相关,但与其他临床特征之间不存在明显相关性。结论 Caspase-8在原发性干燥综合征患者唇腺组织中高表达,且与疾病的病程相关,Caspase-8介导的细胞凋亡途径可能参与了原发性干燥综合征的发病过程。Objective To explore the expression and significance of Caspase-8 in the labial glands of patients with primary Sjogren＇ s Syndrome（pSS） and to analyze the relationship between its expression and the clinical manifestations in pSS. Methods Fifty-five ca- ses with pSS and fifteen controls were collected. Immunohistochemistry and Western blotting were used to examine Caspase-8 protein in labial glands of two groups,the M and the A were measured and the data were analyzed by statistical analysis. Results The expression of Caspase-8 protein in pSS was positively correlated with the disease course and significantly higher than that in control group（P 〈0. 05） ,but had no correlation with the other clinical manifestations, Conclusions The expression of Caspase-8 in pSS has increased, which was related to the disease course. Apoptosis pathway mediated by Caspase-8 may contribute to the formation and progression of pSS.

关 键 词：干燥综合征 唇腺 凋亡 半胱氨酸天冬氨酸蛋白酶-8 

分 类 号：R781.59[医药卫生—口腔医学]