胆囊肉瘤样癌6例及文献复习  

Gallbladder sarcomatoid carcinoma: six cases and literature review

作　　者：秦燕子 欧玉荣[1,2] 马莉[1,2] 张琼[1,2] 武世伍[1,2] 吴礼高[1,2] 陶仪声[1,2] 

机构地区：[1]安徽省蚌埠医学院第一附属医院病理科 [2]蚌埠医学院病理学教研室,安徽省蚌埠市230004

出　　处：《中国肿瘤临床》2015年第4期247-250,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨胆囊肉瘤样癌的临床病理特点、诊断及鉴别诊断。方法:分析6例胆囊肉瘤样癌的临床特点、组织病理学及免疫组织化学特点,进行随访,并复习相关文献。结果:胆囊肉瘤样癌组织病理学上以梭形细胞为主,免疫组织化学提示上皮标记及间叶标记阳性。结论:胆囊肉瘤样癌可以通过组织病理学特点、免疫组织化学标记明确诊断。目前治疗手段以根治性切除为主,但是由于该恶性肿瘤发生率较低,仍需搜集相关病例并长期随访跟踪,找到更好的治疗方法,以提高患者的生存率或生存质量。Objective： To investigate the clinicopathological features, diagnosis, and differential diagnosis of gallbladder sarcomatoid carcinoma. Methods： The clinical manifestations and the microscopic and immunohistochemical characteristics of six patients with gallbladder sarcomatoid carcinoma were analyzed with a follow-up period. Related literature was reviewed. Results：Immunohistochemical markers of gallbladder sarcomatoid carcinoma with spindle cell morphology were epithelial and mesenchymal positivity. Conclusion： Gallbladder sarcomatoid carcinoma could be firmly diagnosed by microscopic morphology and immunohistochemistry. Radical resection is currently used to treat such patients. However, more cases with longer follow-up period are needed to discover better treatments and improve the survival of these patients.

关 键 词：肉瘤样癌 细胞角蛋白 波形蛋白 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]