育龄期女性癫痫患者抗癫痫药物使用的情况  

Condition of antiepileptic drug use in childbearing age female patients with epilepsy

作　　者：马辉[1] 杨丰[1] 武晨[1] 朱葛敏[1] 徐晓霞[1] 魏东[1] 江文[1] 

机构地区：[1]第四军医大学附属西京医院神经内科,西安710032

出　　处：《临床神经病学杂志》2015年第1期49-51,共3页Journal of Clinical Neurology

基　　金：陕西省抗癫痫药物与妊娠登记系统的建立与推广(2012SF2-08-1)

摘　　要：目的探讨育龄期女性癫痫患者的抗癫痫药物使用情况。方法回顾性分析478例育龄期女性患者的药物使用情况。结果 478例患者中,332例患者使用单药治疗,其中133例(40.06%)使用拉莫三嗪,62例(18.67%)使用卡马西平,60例(18.07%)使用丙戊酸钠。96例(20.08%)两药联用,其中36例(32.73%)使用拉莫三嗪+丙戊酸钠。24例(5.02%)使用≥3种药物治疗。26例(5.44%)使用其他药物治疗。结论育龄期女性癫痫患者主要采用单药治疗,以拉莫三嗪为主。单药治疗效果不佳的患者中,以两药联用多见,以拉莫三嗪+丙戊酸钠为主。Objective To investigate the condition of antiepileptic drugs（ AEDs） use in childbearing age female patients with epilepsy. Methods The condition of AEDs use of 478 childbearing age female patients with epilepsy were retrospectively analyzed. Results Among 478 patients,332 patients were used monotherapy,lamotrigine was in 133 cases（ 40. 06%）,carbamazepine was in 62 cases（ 18. 67%）,sodium valproate was in 60cases（ 18. 07%）. Ninty-six patients（ 20. 08%） were combination of both recipes,lamotrigine ＋ sodium valproate was in 36 cases（ 32. 73%）. 24 patients（ 5. 02%） were treatment by more than 3 AEDs,and 26 patients（ 5. 44%）were treatment by the other drugs. Conclusions Childbearing age female patients with epilepsy is mainly adopts monotherapy,and lamotrigine is the predominent AEDs. In patients who not be good therapeutic effect are combination of both recipes,lamotrigine ＋ sodium valproate is the predominent AEDs.

关 键 词：癫痫 育龄期 女性 抗癫痫药物 

分 类 号：R742.1[医药卫生—神经病学与精神病学]