乳腺癌患者血清VEGF、TNF-α和IL-6的表达与预后的相关分析  

Correlation of serum VEGF,TNF- α and IL-6 of patients with breast cancer and prognosis

作　　者：胡金华 张耀晴 朱斌 

机构地区：[1]湖北省京山县人民医院普外2科,湖北京山431899

出　　处：《现代肿瘤医学》2015年第5期639-642,共4页Journal of Modern Oncology

摘　　要：目的:探讨乳腺癌患者血清VEGF、TNF-α和IL-6的浓度变化与乳腺癌分期及侵袭转移的相关性。方法:采用双抗体夹心酶联免疫吸附法(ELISA)测定52例乳腺癌患者(乳腺癌组)和46例乳腺良性肿瘤患者(乳腺良性病组)的血清VEGF、TNF-α和IL-6的浓度,并与40例健康成年人(对照组)比较。结果:乳腺癌组血清VEGF、TNF-α和IL-6水平均高于乳腺良性病组和对照组(P均<0.01)。乳腺癌患者IV期组>III期组>I、II期组(P均<0.01)。伴有腋窝淋巴转移的乳腺癌患者显著高于无腋窝淋巴转移的患者(P<0.01)。结论:外周血VEGF、TNF-α和IL-6水平与乳腺癌的发生发展密切相关,检测其表达水平对判断乳腺癌患者病情进展及预后具有重要意义。Objective： To explore the correlation of serum VEGF, TNF - α and IL - 6 of patients with breast canc- er and its invasion and metastasis. Methods：Serum levels of VEGF,TNF -α and IL -6 were detected by ELISA in 52 cases of breast cancer （ breast cancer group） and 46 cases of benign breast diseases （ benign breast diseases group）, and there were 40 healthy people as control group. Results ：The serum concentrations of VEGF ,TNF - α and IL - 6 in breast cancer group were higher than benign breast diseases group and control group （P 〈 0.01 ） , stage Ⅳ〉 stage Ⅲ〉 stage I and Ⅱ （ P 〈 0.01 ）, and patients with axillary lymphatic metastasis 〉 without metastasis （P〈0.01 ）. Conclusion：The serum levels of VEGF,TNF -α and IL -6 are closely related to the occurrence and de- velopment of breast cancer. There is of great significance of VEGF, TNF - α and IL - 6 serum levels for judging the severity and prognosis of patients with breast cancer.

关 键 词：乳腺癌 VEGF TNF-Α IL-6 肿瘤分期 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]