中晚期宫颈癌腹主动脉旁淋巴结转移治疗的临床研究  

Treatment of advanced cervical cancer patients with isolated para- aortic lymph node metastases

作　　者：韩志红 田小飞 韩星梅 翟振波 杨雪梅 

机构地区：[1]陕西省肿瘤医院妇瘤科,陕西西安710061 [2]长治市第二人民医院妇产科,山西长治046000

出　　处：《现代肿瘤医学》2015年第5期692-694,共3页Journal of Modern Oncology

摘　　要：目的:研究中晚期(Ⅱb-Ⅲb期)宫颈癌腹主动脉旁淋巴结(PALN)转移采用手术和放疗治疗的疗效。方法:选择中晚期(Ⅱb-Ⅲb期)腹主动脉旁淋巴结转移的宫颈癌患者76例,观察组43例,行腹主动脉旁淋巴结清扫术,术后行同步放化学治疗。对照组33例,行宫颈癌同步放化学治疗。分析与患者3年生存率有关的临床病理因素,探讨影响患者预后的因素。结果:手术分期、病理分级、SCCA水平、局部肿瘤大小、腹主动脉旁淋巴结大小、治疗方法与患者的3年生存率有关。多因素分析表明影响患者生存期的因素是分期、分级、局部肿瘤大小、腹主动脉旁淋巴结大小、治疗方法。结论:中晚期宫颈癌腹主动脉旁淋巴结转移,行腹主动脉旁淋巴结切除并辅以术后延伸放疗联合同期化疗,对于病人治疗有重要意义。Objective：To evaluate treatment outcomes of surgery and radiotherapy in advanced cervical cancer pa-tients（Ⅱb - Ⅲb ）with isolated para - aortic lymph node（PALN）metastases. Methods：All 76 cervical cancer pa-tients with isolated PALN node metastases were studied. Study group：Forty - three patients received para - aortic lymphadenectomy resection and postoperative chemoradiotherapy. Control group：Thirty - three patients received ex-tended field chemoradiotherapy. The relationship between survival rate and clinical pathological parameters were as-sessed to explore the factors affecting the prognosis of patients. Results：The 3 - year overall survival rate had correla-tion with tumor stage,histological grade,squamous cell carcinoma antigen（SCC Ag）tumor size,PALN size and treat-ment（P 〈 0. 05）. Multivariate analysis showed that tumor stage,histological grade,tumor size and PALN size were the prognostic factors of patients with cervical cancer（P 〈 0. 05）. Conclusion：In cervical cancer with isolated para - aor-tic lymphnode metastasis para - aortic lymphadenectomy resection and postoperative chemoradiotherapy is important in treatment.

关 键 词：中晚期宫颈癌 腹主动脉旁淋巴结转移 预后 

分 类 号：R737.33[医药卫生—肿瘤]