非小细胞肺癌患者血清中细胞因子(IL-2、IL-4、IL-6、IL-10)的含量与临床分期的关系  

Relationship between cytokines( IL-2,IL-4,IL-6,IL-10 ) and clinical stage in non-small cell lung cancer patients

作　　者：戴春[1] 周永春 黄云超[1] 李恒[1] 张祥武[1] 赵光强[1] 雷玉洁[1] 陈安宁[1] 叶联华[1] 杨凯云[1] 

机构地区：[1]昆明医科大学第三附属医院胸心外科,云南昆明650118 [2]云南省肿瘤研究所,云南昆明650118

出　　处：《现代肿瘤医学》2015年第6期779-781,共3页Journal of Modern Oncology

基　　金：国家自然科学基金重点项目(编号:U1202224);国家自然科学基金(编号:81460441);云南省应用基础研究联合项目(编号:2013FB165)

摘　　要：目的:从细胞因子角度探讨非小细胞肺癌患者免疫功能的变化与临床分期的关系。方法:用ELISA法检测50例肺癌患者和15例健康志愿者血清中IL-2、IL-4、IL-6、IL-10的含量,并进行统计分析。结果:非小细胞肺癌患者血清中IL-2、IL-4、IL-6、IL-10的表达水平均明显高于健康志愿者(P<0.05)。Ⅱ期患者血清中IL-6的含量显著高于I、Ⅲ、Ⅳ期患者;Ⅱ期和Ⅲ期非小细胞肺癌患者血清中IL-10的含量高于I期和Ⅳ期患者。结论:IL-2、IL-4、IL-6、IL-10均参与了肺癌的发展,检测其血清含量对了解肺癌患者体内免疫状态和预后判断有重要意义。Objective：To detect the cytokines and explore the change of immune function of non-small cell lung cancer patients and the relationship with clinical stage.Methods：To detect serum IL 2,IL 4,IL-6,IL-10 levels in50 patients with lung cancer and 15 cases of healthy volunteers by ELISA method.Results：The serum levels of IL-2,IL-4,IL-6 and IL-10 in patients with lung cancer were significantly higher than those of healthy subjects（ P〈0.05）.The serum levels of IL-2 and IL-4 in patients with lung cancer were closely correlated with tumor＇s TNM stages.IL-6 content peaked in stage Ⅱ and declined in stage Ⅲ,Ⅳ.The content of IL-10 increased in stage Ⅱand Ⅲ,declined in stage Ⅳ.Conclusion：The expressions of IL-2,IL-4,IL-6 and IL-10 are increased in patients with lung cancer.IL-2,IL-4,IL-6 and IL-10 are involved in the development and metastasis of lung cancer.The detection of the serum levels of these cytokines plays an important role in understanding the patients immunological status and evaluating prognosis.

关 键 词：白介素2 白介素4 白介素6 白介素10 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]