软骨损伤动物模型的建立及分析方法  

Methods to analysis and establish the animal model of articular cartilage injury

作　　者：吴宁[1] 刘武[1] 

机构地区：[1]广西中医药大学,广西南宁530001

出　　处：《大众科技》2015年第1期105-107,共3页Popular Science & Technology

摘　　要：目的:总结软骨损伤动物模型的建立及分析方法。方法:查阅软骨损伤动物模型的建立及分析方法的相关文献。结果:软骨损伤动物模型的建立主要从动物的选择、损伤部位、损伤方法以及损伤后的软骨分析等方面考虑,经过分析得出最符合人类急性应力损伤的造模方法,即撞击法。结论:软骨损伤动物模型的建立及分析方法很多,效果及应用各异。软骨损伤动物模型的损伤机制与人类之损伤机制越相似,治疗及相关研究就越有价值。由于撞击法模拟人类软骨急性损伤机制,因此撞击法建立软骨损伤动物模型备受重视。Objective：To review the methods to analysis and establish the animal model of articular cartilage injury. Methods：Recent literatures about the method of analyzing and establishing cartilage injury animal model were reviewed. Results：Methods to establish the animal model of cartilage damage mainly from aspects of animal selection, site of injury, means of injury and analysis of cartilage damage considering, the molding method of the most consistent with human acute stress damage, namely the impact method. Conclusion：A lot of methods to selection to analysis and establish the cartilage injury animal model,which application and effect is different. Injury mechanism of human and injury mechanism of animal models of cartilage injury more similar, treatment and related research is more valuable. Because the impact method to simulate human acute osteochondral injury mechanism, thus it will be pay more and more attention to establish animal model of cartilage injury.

关 键 词：软骨损伤 动物模型 方法 

分 类 号：R-33[医药卫生]