微小RNA-9在癌症及神经退行性疾病中的研究现状  

Research status of microRNA-9 in cancers and neurodegenerative disease

作　　者：李晓琳[1] 胡雪玲[1] 孙丽华[1] 

机构地区：[1]哈尔滨医科大学药学院药理教研室,哈尔滨150086

出　　处：《中国临床药理学杂志》2015年第4期315-316,320,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81000499;81371211);哈尔滨医科大学药学院大学生创新基金资助项目

摘　　要：微小RNA-9(miR-9)家族是一类非编码小分子单链RNA,能通过参与基因转录后修饰调控基因的表达。近年来,癌症的发病率逐年升高,研究其机制和治疗方法具有十分重要的意义。许多类型的癌症都出现miR-9的表达量异常,提示miR-9可能与肿瘤的形成或发展有关。本文主要讨论miR-9在多种癌症和神经系统相关疾病中的研究现状,重点阐述miR-9在乳腺癌、胃癌、结肠癌、食管癌、人神经母细胞瘤和神经退行性疾病中的作用。MicroRNA- 9（ miR- 9） family is a kind of non- coding small single- stranded RNA,by participating in the genes of post- translational modifications to regulate gene expression. In recent years,the incidence of cancer rises year by year. To study its mechanism and treatment has great significance. According to recent studies,the quantity of miR- 9 expression in many types of cancers is abnormal,suggesting miR- 9 may be associated with the formation or development of tumors. This article mainly discuss the research progress of miR- 9 in many cancers and nerve system diseases,emphasis on the effect of miR- 9 in breast cancer,gastric cancer,colon cancer,esophagus cancer,neuroblastoma and neurodegenerative disease.

关 键 词：微小RNA-9 神经退行性疾病 癌症 

分 类 号：R730[医药卫生—肿瘤] R968[医药卫生—临床医学]