气相色谱法测定盐酸头孢卡品酯中甲醇等6种溶剂残留量方法研究  

GC method determination of residual solvent in cefcapene pivoxil hydrochloride

作　　者：鲁瑞娟[1] 李立俭[1] 曹晓云[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《天津药学》2015年第1期22-24,共3页Tianjin Pharmacy

摘　　要：目的：建立盐酸头孢卡品酯中甲醇等6种溶剂残留量的测定方法。方法：采用DB-624毛细管色谱柱,程序升温,FID检测器,载气为氮气,以乙醇为内标物测定盐酸头孢卡品酯中甲醇、丙酮、二氯甲烷、正己烷、异丙醚和乙酸乙酯6种溶剂的残留量。结果：6种溶剂在所考查的浓度范围内均具有良好的线性关系,相关系数均为0.99以上,6种溶剂的回收率均在90.0%~110.0%之间。结论：本方法专属性强,操作简便,结果可靠,适用于盐酸头孢品酯中残留溶剂的测定。Objective： To eastablish a method for determination of residual solvent in cefcapene pivoxil hydrochloride. Methods：The capillary column was DB- 624,Tempreture programming. The capillary carrier gas was nitrogen,FID detector. Determination of six residual solvents in cefcapene pivoxil hydrochloride using ethanol as an internal standard. Result： Under the above condition,there were good linearies,the correlation coefficients were above 0. 99,six kinds of solvent the recoveries were between 90. 0% ~110. 0%. Conclustion： The methods was simple,accurate and reproducible. it can be used for determination of residual solvent.

关 键 词：气相色谱法 盐酸头孢卡品酯 残留溶剂 

分 类 号：R927.11[医药卫生—药学]