合用与换用阿立哌唑对已绝经女性精神分裂症患者催乳素水平影响的对照研究  

Control Study of Combined with Aripiprazole or Switching to Aripiprazole on Prolactin Levels in Postmenopausal Women with Schizophrenia

作　　者：倪静[1] 戴兴海[1] 朱欣彦[2] 沈涛[1] 周颖[1] 田良辉[1] 咸晶 徐颺 

机构地区：[1]上海市黄浦区精神卫生中心,上海黄浦区200003 [2]同济大学附属东方医院消化科,上海黄浦区200003

出　　处：《河北医学》2015年第4期591-594,共4页Hebei Medicine

摘　　要：目的:探讨已绝经女性精神分裂症合并高催乳素血症患者在合用与换用阿立哌唑时对其催乳素水平影响的对照研究。方法:对90例已绝经女性精神分裂症同时合并高催乳素血症的患者随机分为两组,合用组:45例,为原有药物联合阿立哌唑5mg/d治疗12周,换用组:45例,为原有药物更换为治疗剂量阿立哌唑(14.78±4.76mg/d)12周,治疗前和治疗后2、4、8、12周末分别测定催乳素水平并予以阳性和阴性量表(PANSS)和副反应量表(TESS)评定病情并进行比较。结果:根据重复测量结果,两组间PRL水平尚无统计学差异(F=3.507,P=0.064),但组间检验提示时间、研究组别有交互作用(P=0.002),即PRL的值受到时间和组别的共同影响。PRL随着时间的推移逐渐下降,且换用组下降的幅度大于合用组。两组间PANSS量表总分无统计学差异(F=0.145,P=0.705)。结论:无论合用阿立哌唑治疗组或是换用阿立哌唑治疗组,均能使已绝经女性精神分裂症患者的高催乳素水平下降,但换用阿立哌唑治疗,催乳素水平下降幅度更大。Objective： To investigate the role of aripiprazole in prolactin（ PRL） metabolism through comparing the PRL levels of the postmenopausal women with schizophrenia and hyperprolactinemia.Method：90 women with schizophrenia and hyperprolactinemia were randomly divided into 2 groups： group A with 45 cases,former drugs plus aripiprazole 5mg once a day for 12 weeks） and group B with 45 cases,Aripiprazole14.78±4.76 mg once a day for 12 weeks）. Then examined the PRL levels at 5 time points： prior treatment,2weeks,4 weeks,8 weeks,12 weeks and accomplished the PANSS scales at the time points stated above as well.Result： According to the result of repeated measures ANOVA,the PRL levels of the 2 groups had no significant differences（ F = 3.507,P = 0.064） and had interaction between the groups and time points（ P = 0.002）,suggesting that PRL was influenced by different treatment of aripiprazole and time. The score of PANSS scales had no significant differences（ F = 0.145,P = 0.705）.Conclusion： Aripiprazole may down-regulate the expression of the PRL levels of women with schizophrenia and hyperprolactinemia.

关 键 词：阿立哌唑 绝经女性 精神分裂症 高催乳素血症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]