FAK、NF-κBp65及VEGF-C在肺鳞癌和肺腺癌中的表达及意义  

Expression and significance of FAK,NF-κBp65 and VEGF-C in squamous cell carcinoma of lung and adenocarcinoma

作　　者：张柯晴 吕坤聚[2] 朱君祥[2] 

机构地区：[1]青岛大学医学院,山东青岛266071 [2]中国人民解放军第401医院呼吸内科,山东青岛266071

出　　处：《临床肺科杂志》2015年第4期603-606,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨FAK、NF-κBp65及VEGF-C在肺鳞癌及肺腺癌中的表达与NSCLC临床特征的关系。方法采用免疫组织化学Elivision法检测FAK、NF-κBp65及VEGF-C在75例肺鳞癌和肺腺癌中的表达情况,以30例对应的癌旁正常组织作为对照。结果在癌组织中FAK、NF-κBp65、VEGF-C的阳性表达率分别为57.3%(43/75)、85.3%(64/75)、65.3%(49/75),而在癌旁组织中三者的阳性率分别是13.3%(4/30)、16.7(5/30)、0%(0/30),FAK、NF-κBp65、VEGF-C的表达与肿瘤的分化程度、临床分期、淋巴结转移等密切相关,差异有统计学意义(P<0.05)。结论 FAK、NF-κBp65、VEGF-C的高表达在肺鳞腺癌的发生和发展中起重要作用,以三者为中心的靶向治疗,可能成为肺癌治疗的新方法。Objective To investigate the expression of FAK,NF-kappa BP65 and VEGF-C in squamous cell carcinoma of lung and adenocarcinoma in order to detect their relationship with the clinical pathologic feature of patients with squamous cell carcinoma of lung and adenocarcinoma. Methods The immunohistochemical staining method was used to detect the expression of FAK（ focal adhesion kinase）,NF-κBP65（ nuclear factor-kappa BP65）and VEGF-C（ vascular endothelial growth factor-C） in squamous cell carcinoma of lung and adenocarcinoma（ n =75） and 30 normal cancer tissues. Results The positive rates of FAK,NF-κBp65 and VEGF-C expression were57. 3%（ 43 /75）,85. 3%（ 64 /75） and 65. 3%（ 49 /75） in cancer tissues and 13. 3%（ 4 /30）,16. 7%（ 5 /30）and 0%（ 0 /30） in normal tissues. The expression level of FAK,NF-κBp65 and VEGF-C was closely related with cell differentiation,clinical stages and lymph node involvement（ P〈0. 05）. Conclusion The high expression of FAK,NF-κBp65 and VEGF-C plays a crucial role in the carcinogenesis and progress of lung cancer. The targeting treatment to FAK,NF-κBp65 and VEGF-C may be a novel mean for lung cancer.

关 键 词：FAK NF-ΚB VEGF 免疫组织化学 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]