VEGF-C与p27在子宫内膜癌中的表达及其相关性研究  

Expression and Correlation of VEGF-C and p27 in Endometrial Carcinoma

作　　者：陈灿 梁艳芳 

机构地区：[1]广东省东莞市第五人民医院病理科,东莞523905

出　　处：《实用中西医结合临床》2015年第1期1-3,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨VEGF-C和p27在子宫内膜癌和增生性子宫内膜中的表达及其相关性,并分析其临床意义。方法:采用免疫组织化学检测51例子宫内膜癌和45例增生性子宫内膜组织中VEGF-C和p27的表达,并结合临床病理特征进行相关性分析。结果:子宫内膜癌中VEGF-C阳性表达率明显高于增生性宫内膜及正常子宫内膜组织(χ2=4.571,χ2=0.235,P<0.01),差异有统计学意义;子宫内膜癌中p27阳性表达率明显低于增生性子宫内膜及正常子宫内膜组织(χ2=10.227,χ2=2.113,P<0.05),差异有统计学意义。在对子宫内膜癌组织的分析中,VEGF-C的阳性表达率与子宫内膜癌的病理分级呈正相关,与肿瘤分化、肌层浸润程度和临床分期有关(P<0.05);p27表达与肿瘤分化及临床分期有关(P<0.05),与肌层浸润深度无关(P>0.05)。VEGF-C表达率与p27表达率呈明显负相关。结论:VEGF-C与p27基因在子宫内膜不同组织中存在差异表达,并且两者具有相关性,提示两者在子宫内膜癌发生、发展及侵袭浸润中起重要作用,有可能成为判断预后的重要指标之一,具有一定的临床参考意义。Objective： To study the expression and correlation of VEGF-C and p27 in proliferative endometrium and endometrial carcinoma. Methods： The expression of VEGF-C and p27 were detected by immunohistochemistry in 51 cases of endometrial carcinoma and 45 cases of endometrial hyperplasia tissues. The correlation was analyzed in the context of clinical pathological characteristics. Results： The positive expression of VEGF-C was significantly higher than that of proliferative endometrium and normal endometrium rate of endometrial carcinoma （χ^2=4.571, χ^2=0.235, P〈0.01）, the difference being statistically significant; the positive expression of p27 was lower than that of hyperplastic endometrial carcinoma and normal endometrial tissue rate of endometrial carcinoma （χ^2 =10.227, χ^2=2.113, P〈0.05）, the difference also being statistically significant. According to the analysis of endometrial cancer tissue, pathological grading and VEGF-C positive expression rate were positively related with endometrial carcinoma, tumor differentiation, the degree of myometrial invasion and clinical stage （P〈0.05）; the expression of p27 was associated with tumor differentiation and clinical stage （P〈0.05）, and was independent of the depth of myometrial invasion （P〉0.05）. The expression rate of VEGF-C and p27 expression rate witnessed significantly negative correlation. Conclusion： VEGF-C and p27 gene expression in different tissue differs in endometrium and there is a correlation between them. This suggests that the two factors in endometrial cancer occurrence and development and that they play an important role in the invasion and therefore have the potential to become one of the important indicators of prognosis as they have certain clinical significance.

关 键 词：子宫内膜癌 增生性子宫内膜 VEGF-C P27 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]