护骨素和可溶性核因子кB受体活化因子配体在非小细胞肺癌诊断和鉴别诊断中的意义  

Clinical significance of serum sRANKL/OPG in diagnosis and differential diagnosis of non-small cell lung cancer

作　　者：陈明治[1] 蒋国军[1] 谈永飞[1] 王洪敏[1] 唐巍峰[2] 谈志刚[1] 龚泽刚[1] 史国振[1] 

机构地区：[1]江苏大学附属宜兴人民医院胸心外科,宜兴214200 [2]江苏大学附属人民医院胸心外科,镇江212001

出　　处：《中国肿瘤临床与康复》2015年第3期261-263,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨护骨素(OPG)和可溶性核因子кB受体活化因子配体(sRANKL)在非小细胞肺癌(NSCLC)诊断和鉴别诊断中的意义。方法分别选取50例NSCLC患者、25例肺部良性占位患者和25例正常体检者,采用酶联免疫吸附法检测患者中血清OPG和sRANKL的水平。结果NSCLC组的sRANKL水平和sRANKL/OPG比值均高于良性占位组和正常体检组(P<0.05);三组间OPG水平比较,差异无统计学意义(P>0.05)。血清sRANKL和sRANKL/OPG比值诊断NSCLC的最佳截断点分别为>4.20 pmol/L和>0.60,sRANKL诊断的敏感度、特异度和准确性分别为74.0%、84.0%和77.3%,sRANKL/OPG比值诊断的敏感度、特异度和准确性分别为84.0%、88.0%和85.3%。血清sRANKL和sRANKL/OPG比值鉴别诊断肺部良恶性占位病变的最佳截断点分别为>5.24 pmol/L和>0.63,sRANKL鉴别诊断的敏感度、特异度和准确性分别为60.0%、84.0%和68.0%,sRANKL/OPG比值诊断的敏感度、特异度和准确性分别为78.0%、64.0%和73.3%。结论血清sRANKL水平和sRANKL/OPG比值可作为NSCLC的辅助诊断指标。Objective To investigate the significance of osteoprotegerin（OPG） and soluble receptor activator of nuclear factor-r：B ligand（sRANKL） in non-small cell lung cancer（NSCLC） patients. Methods Serum OPG and sRANKL levels were detected in 50 NSCLC patients, 25 patients with benign lung nodule and 25 heahhy controls using enzyme-linked immunosorbent assay（ELISA）. Results The sRANKL level and sRANKL/OPG ratio in the NSCLC group were higher than the other two groups （ P 〈 0.05 ）, whereas the levels of serum OPG were consistent（ P 〉 0.05 ）. The best cut-off points of serum sRANKL and sRANKL/OPG ratio for diagnosing NSCLC were 〉 4. 2 pmol/L and 〉 0. 6, respectively, with the diagnostic sensitivity, specificity and accuracy of 74. 0% ,84.0% ,77. 3% and 84. 0% ,88.0% ,85.3% ,respectively. The best cut-off points of serum sRANKL and sRANKL/OPG ratio for differential diagnosis of NSCLC were 〉 5.24 pmol/L and 〉 0. 63, respectively, with the diagnostic sensitivity, specificity and accuracy of 60. 0%, 84. 0% and 68.0%, 78.0%, 64. 0% and 73.3%, respectively. Conclusion Serum sRANKL and sRANKL/OPG ratio may be promising in the auxiliary diagnosis of NSCLC.

关 键 词：护骨素 可溶性核因子кB受体活化因子配体 癌 非小细胞肺 

分 类 号：R734.2[医药卫生—肿瘤]