Ⅰ型胶原羧基端前肽和β胶原降解产物在乳腺癌骨转移诊断和随访中的价值  

Bone metabolic markers in the diagnosis and follow-up of breast cancer patients with bone metastases

作　　者：宋斌斌[1] 李侠[1] 屠美萍[1] 杨新妹[1] 陈慧[1] 周强[1] 江一鸣[1] 王爱芬[1] 

机构地区：[1]浙江省嘉兴市第一医院肿瘤内科,嘉兴314000

出　　处：《中国肿瘤临床与康复》2015年第3期270-272,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：嘉兴市科技局计划项目(SQ2012010090)

摘　　要：目的探讨Ⅰ型胶原羧基端前肽(PICP)和β胶原降解产物(β-CTx)在乳腺癌骨转移诊断和随访中的应用价值。方法将114例乳腺癌患者分为骨转移组(56例)和无骨转移组(对照组,58例)。对照组根据腋窝淋巴结转移情况分为p N0组(12例)、p N1组(15例)、p N2组(19例)和p N3组(12例),根据激素受体情况分为Lumina型组(30例)和非Lumina型组(28例)。分别测定114例患者血清中PICP和β-CTx的水平。结果骨转移组PICP和β-CTx的水平均高于对照组,差异有统计学意义(P<0.05)。对照组中,p N0组、p N1组、p N2组以及p N3组间的PICP和β-CTx水平比较,差异无统计学意义(P>0.05);非Lumina型组的PICP和β-CTx水平高于Lumina型组,差异有统计学意义(P<0.05)。对照组患者有7例无症状患者在随访过程中出现骨代谢指标异常升高,进一步检查发现有5例出现骨转移。结论骨代谢指标能够早于常规影像学检查提示骨转移的发生,在乳腺癌骨转移的诊断和远期随访中具有重要价值。Objective To explore the application of the carboxyl terminal propeptide of type I collagen（ PICP） and beta collagen degradation products（ β-CTx） in diagnosis and follow-up of breast cancer patients with bone metastases. Methods 114 breast cancer patients were divided into the bone metastases group（ 56 cases） and the non-bone metastases group（ the control group,58 cases）. The control group was divided into p N0 group（ 12 cases）,p N1 group（ 15 cases）,p N2 group（ 19 cases） and p N3 group（ 12 cases） according to the axillary lymph node metastasis; the Lumina group（ 30 cases） and the non Lumina group（ 28cases） according to the hormone receptor. The PICP and β-CTx were both detected and compared between the different groups. Results The PICP and β-CTx of the bone metastases group were higher than the control group（ P〈0. 05）. However,the PICP and β-CTx were consistent in the PN0 group,PN1 group,PN2 group and PN3 group. The PICP and β-CTx of the Non Lumina group were higher than the Lumina group（ P〈0. 05）. The PICP and β-CTx of 7 asymptomatic patients increased during the follow-up,5 cases with bone metastasis after further examination. Conclusion The PICP and β-CTx have important value in diagnosis and long-term follow-up in breast cancer with bone metastases.

关 键 词：I型胶原羧基端前肽 β胶原降解产物 乳腺肿瘤 骨转移 

分 类 号：R737.9[医药卫生—肿瘤]