9850例孕妇中期血清唐氏综合征筛查结果分析  

Screening analysis of Down syndromes in 9850 cases on middle period pregnancy

作　　者：王欢[1] 肖婕[1] 张万兴[1] 李玲[1] 袁金兰[1] 

机构地区：[1]江西省吉安市妇幼保健院遗传室,343000

出　　处：《中国优生与遗传杂志》2015年第3期44-44,115,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过检测妊娠中期孕妇血清甲胎蛋白,游离β绒毛促性腺激素指标筛查出唐氏综合征高危人群。方法对9850例孕14-20W孕妇采用酶联免疫法使用其配套软件计标其风险系数。结果在9850例孕妇中筛查出高风险孕中期孕妇810例,筛查阳性率唐氏综合征为7.78%,NTD0.38%。在810例高危孕妇中有345例知情同意进行了羊水细胞染色体核型分析,胎儿染色体异常19例,异常检出率为4.64%。其中数目异常10例占52.63%,结构异常9例47.37%。结论通过筛查可减少盲目性,为实现优生,减少出生缺陷具有重要意义。Objective：To screen out high-risk groups of Down′s syndrome by testing serum AFP of middle period pregnant women and the level of Free β-HCG. Methods：Take ELISA on 9850 pregnant women of 14-20 weeks,use auxiliary software to calculate the risk coefficients. Results：Screening out 810 high-risk middle period pregnant women from the 9850 cases. The positive rate of Down′s syndrome is 7.78% and the rate of NTD is 0.38%. Among the 810 high-risk pregnant women,there are 345 cases agree to make the karyotype analysis of amniotic fluid cells after being informed. 19 cases are fetus chromosomal abnormal,the detection rate is 4.64%. Among the 19 cases,10 cases are number abnormal accounting for 52.63%,9 cases are structure abnormal accounting for 47.37%. Conclusion：Screening can reduce blindness. It has important significance to achieve birth health and lower birth defects.

关 键 词：产前筛查 产前诊断 

分 类 号：R714.5[医药卫生—妇产科学]