异甘草酸镁对老年人药物性肝损伤的疗效观察  

Effects of magnesium isoglycyrrhizinate in the elderly with drug-induced liver injury

作　　者：金玉玲[1] 邱昕光[1] 

机构地区：[1]武汉科技大学附属天佑医院干部病区,湖北省武汉市430064

出　　处：《实用老年医学》2015年第2期119-120,124,共3页Practical Geriatrics

摘　　要：目的观察异甘草酸镁治疗老年人药物性肝损伤的临床疗效。方法选取76例老年患者随机分为观察组和对照组各38例,2组均给予常规保肝治疗,观察组在对照组基础上加用异甘草酸镁注射液,疗程结束后比较2组的总有效率。结果观察组显效率为57.9%,总有效率为92.1%,明显优于对照组的36.8%和63.2%,差异有统计学意义(P<0.05);且治疗后观察组肝功能指标下降更明显,差异有统计学意义(P<0.01)。结论异甘草酸镁能提高常规治疗老年人药物性肝损伤的临床疗效,且具有良好的安全性。Objective To observe the clinical efficacy of magnesium isoglycyrrhizinate in the elderly with drug-induced liver injury. Methods Seventy-six cases of elderly patients were randomly divided into observation group and control group,with 38 cases in each group. Both groups were given routine liver protection treatment,and the observation group received magnesium isoglycyrrhizinate based on the routine treatment. The total efficacy after treatment was compared between two groups. Results The significant effective rate and the total effective rate in the observation group was57. 9% and 92. 1%,compared with 36. 8% and 63. 2% in the control group,with significant difference（ P〈0. 05）. The levels of liver function indexes of the observation group decreased more significantly after treatment（ P〈0. 05）. Conclusions Magnesium isoglycyrrhizinate can improve the clinical efficacy of conventional treatment in elderly patients with drug-induced liver injury,with a good safety.

关 键 词：异甘草酸镁 药物性肝损伤 老年人 

分 类 号：R575[医药卫生—消化系统]