中老年人自评健康与轻度认知障碍的相关性  

Correlation between self-rating health and mild cognitive impairment in middle-aged and elderly residents

作　　者：许少君[1] 江朝强[1] 张维森 郑家强[2] 徐琳[3] 刘斌[1] 靳雅丽[1] 朱彤[1] 林大庆[3] 

机构地区：[1]广州医科大学附属第十二人民医院穗港英合作分子流行病学研究室,广东省广州510620 [2]英国伯明翰大学公共卫生与流行病学系 [3]香港大学公共卫生学院

出　　处：《中国慢性病预防与控制》2015年第2期96-100,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：广州市科技和信息化局立项资助(2013J4100031;2012J5100041);广州市医药卫生科技项目重大项目资助(201102A211004)

摘　　要：目的探讨中老年人自评健康（SRH）与轻度认知障碍（MCI）的相关性,为早期发现老年痴呆高危人群,防控老年痴呆提供参考。方法基于＂广州生物库队列研究＂（GBCS）平台,选取27 888名50岁以上广州中老年人的基线资料,采用协方差分析和非条件logistic回归模型分析SRH与10个单词延迟记忆测试（DWRT）和MCI的相关性。MCI定义为DWRT小于4分。结果基于与同龄人比的SRH,自评良好组DWRT得分为5.56（95%CI：5.49～5.64）分,显著高于自评一般组[5.38（95%CI：5.31～5.45）分]和较差组[5.30（95%CI：5.21～5.38）分],差异均有统计学意义（t值分别为7.30、7.10,P〈0.01）。与自评良好组比,自评一般组和较差组患MCI的风险分别增加24%（95%CI：13%～35%）和45%（95%CI：27%～66%）,差异有统计学意义（Waldχ^2=34.68,P〈0.01）。基于自身总体感觉的SRH,自评好者DWRT得分[5.44（95%CI：5.37～5.51）分]显著高于自评差者[5.36（95%CI：5.29～5.44）分],差异有统计学意义（F=8.60,P〈0.01）。自评差者患MCI风险相对自评好者增加23%（95%CI：13%～35%）,差异有统计学意义（Waldχ^2=20.96,P〈0.01）。选相对健康者做敏感性分析或按性别分层分析,结果与上述一致。结论自评健康差与MCI有关,对自评健康差者进行认知障碍测试和合理干预可能有助于防控老年痴呆。Objective To explore the correlation between self-rating health（SRH） and mild cognitive impairment（MCI）, to early detect the population with high risk of senile dementia and to provide reference for the prevention and control of senile dementia.Methods On the basis of the Guangzhou Biobank Cohort Study（GBCS）, the basic data of 27 888 residents ≥ 50 years old were selected. The association of SRH with Delayed 10-Word Recall Test（DWRT） and MCI was analyzed using covariance and nonconditional logistic regression, respectively. MCI was defined as the DWRT scores less than 4 points. Results According to SRH comparing to residents with same age, DWRT score in the good SRH group was 5.56（95%CI： 5.49-5.64）, which was significantly higher than that（5.38, 95%CI： 5.31-5.45） in the common SRH group and that（5.30, 95%CI： 5.21-5.38） in the low SRH group（P〈0.01）. As compared to the good SRH group, the risk of MCI in the common SRH group and the low SRH group increased 24%（95%CI： 13%-35%）and 45%（95%CI： 27%-66%）, respectively（P〈0.01）. On the basis of total SRH, DWRT score in the good SRH group was 5.44（95%CI： 5.37-5.51）, which was significantly higher than that（5.36, 95%CI： 5.29-5.44） in the low SRH group（P〈0.01）. As compared to the good SRH group, the risk of MCI in the low SRH group increased 23%（95%CI： 13%-35%,P〈0.01）. Sensitivity analysis for relative healthy residents or stratified analysis by gender also showed similar results. Conclusion The poor SRH is associated with MCI, the testing cognitive impairment and reasonable intervening for residents with low SRH may be helpful for preventing senile dementia.

关 键 词：自评健康 轻度认知障碍 中老年人 相关性 

分 类 号：R749[医药卫生—神经病学与精神病学]