维持治疗期间不同剂量氨磺必利对精神分裂症认知功能及临床疗效的影响  

Different Doses of Amisulpride's Influence on the Cognitive Function and the Clinical Curative Effect for Schizophrenia during Maintaining Treatment

作　　者：聂所成[1] 刘长成[1] 张新风[1] 蒋平[1] 涂哲明[1] 刘波[1] 

机构地区：[1]湖北省荆州市精神卫生中心,中国434000

出　　处：《中国健康心理学杂志》2015年第2期167-170,共4页China Journal of Health Psychology

摘　　要：目的：探讨维持治疗期间不同剂量氨磺必利对精神分裂症认知功能及远期疗效的影响。方法：采用2012年3月一2013年3月在我院住院采用氨磺必利治疗并获得临床痊愈的精神分裂症患者，共96例。随机分为全剂量组和半剂量组，急性期治疗3个月后，全剂量组（46例）维持原治疗剂量600～800mg／d；半剂量组（50例）给予原治疗量的一半作维持量300～400mg／d，纳入病例在出院后持续随访1年，采用韦氏成人智力量表（WAIS）、临床记忆量表评价认知功能，采用阳性与阴性症状量表（PANSS）、大体评定量表（GAS）来衡量评价临床疗效。结果：1年随访后两组认知功能比较差异显著，WAIS量表：言语智商、操作智商、总智商（t=6．1276，3．2526，5．1423；P〈0．05）；记忆量表：联想学习、图像自由回忆、人像特点回忆及记忆商数（t=3．0972，3．3938，3．0565，2．8937；P〈0．05）。两组临床疗效比较：PANSS总分（t=3．6915，P〈0．05）；GAS量表评分（t=9．5153，P〈0．05）；1年累计缓解率分别为82．2％和60．4％（χ^2=5．32，P〈0．05）；复发率分别为15．22％和34．oo％（0=4．51，P〈0．05）。副作用发生率分别为45．65％和34．00％（χ^2=1．36，P〉0．05）。结论：采用氨磺必利全治疗剂量维持治疗对认知功能改善明显，远期疗效较好、复发率较少。Objective：To explore the influence of different doses of amisulpride on cognitive function for schizophrenia and long- term curative effect during maintaining treatment. Methods：From March 2012 to March 2013 ,a total of 96 cases of schizophrenia inpatients who got clinical cure with amisulpride treatment, were randomly divided into the total dose and half dose group. After three months of acute treat- ment, the total dose. group （46 cases）which maintained 600 -800mg/d of the original treatment dose, The half dose group （ 50 cases） which just were given half amount of maintenance dose （ 300 - 400mg/d） of the original treatment were included in cases. Following discharged continuously one year of follow - up, eval- uating cognitive function through Weehsler Adult Intelligence Scale （WAIS）and the clinical memory scale, measuring and evaluating the clinical efficacy through PANSS, GAS scale. Results： After a year fol- low - up ,there were significant differences between two groups in WAIS ： Both verbal IQ, performance IQ and total IQ（ t = 6. 1276,3. 2526,5.1423 ;P 〈 0. 05 ）, Memory Scale：Associative learning,free image re- call, portraits feature memory and memories quotient （ t = 3. 0972,3. 3938,3. 0565,2. 8937 ; P 〈 0.05 ）, PANSS（t =3.6915 ,P 〈0.05） ,GAS（t =9. 5153 ,P 〈0.05） ;The rate of one - year accumulative total remission was 82.2% and 60.4% respectively（ t = 5.32 ,P 〈 0.05 ） ;Recurrence rates were 15.22% and 34% （ t = 4.51,P 〈 0.05 ）. The rate of adverse events were 45.65 % and 34% （ χ^2 = 1.36, P 〉 0.05 ）. Conclusion：The full therapeutic dosage of amisulpride maintenance therapy can significantly improve the cognitive function, with good long- term effect, less recurrence rate.

关 键 词：精神分裂症 氨磺必利 认知功能 临床疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]