肿瘤-睾丸基因在肝细胞癌诊断和治疗中的研究进展  

The research progress of cancer-testis genes in hepatocellular carcinoma

作　　者：张征委 黄华兴[1] 

机构地区：[1]南京医科大学第一临床医学院,211100

出　　处：《国际免疫学杂志》2015年第2期192-194,共3页International Journal of Immunology

摘　　要：原发性肝癌是我国常见恶性肿瘤之一。因其恶性度高、病情进展快，病人一旦出现症状就诊往往已属中晚期，故治疗难度大、疗效差，一般发病后生存时间仅为6个月，死亡率在消化系统恶性肿瘤中列第3位。目前，因为肿瘤．睾丸抗原（CTA）在肝细胞癌诊治中所展现的优越性已引起了广泛关注，编码该抗原的基因被称为肿瘤-睾丸基因。已有不少学者在肝细胞癌中开展了一些CTA的基础研究。One of the most frequent liver cancer in China is hepatocellular carcinoma（HCC）. It is often detected at late stage because of its malignancy and fast progress. The average survival time is only about six months after onset, making it the third leading cause of cancer death in malignant tumors of digestive systems . Currently, cancer-testis antigens （CTA） cause wide public concern because of its development in the diagnosis and treatment of HCC. The genes which encode CTA are called as cancer - testis genes. Some scientists have carried out basic researches about CTA in hepatocellular carcinoma.

关 键 词：肝细胞癌 肿瘤-睾丸抗原 诊断 治疗 

分 类 号：R735.7[医药卫生—肿瘤]