认知障碍简明评价量表对老年人认知功能衰退的预测价值初探  

Value of Cog-12 in predicting cognitive impairment in the elderly

作　　者：潘晓东[1] 周辰[1] 徐俊[1] 何一然[1] 尹冬华[1] 张长春[1] 顾小花[1] 

机构地区：[1]江苏省老年医学研究所,南京210009

出　　处：《中华老年心脑血管病杂志》2015年第3期235-238,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：江苏省干部保健专项资金科研课题(GB13-057)

摘　　要：目的探讨认知障碍简明评价量表(Cog-12)对老年人认知功能下降的预测能力。方法选择56例患者,其中基线水平认知正常29例和轻度认知功能障碍(MCI)27例,将基线与随访2年认知均正常18例作为NC组,认知正常转为MCI 11例作为CM组,基线及随访2年保持MCI状态作为10例MM组,MCI转化为阿尔茨海默型痴呆11例作为AD组。在初入组及随访2年后,分别通过知情者或照料者对患者进行Cog-12、蒙特利尔认知评估量表(MoCA)、简易智能状态检查量表(MMSE)评分,对患者的认知能力进行评价。结果认知正常者中,NC组的MoCA、MMSE评分较CM组明显升高,Cog-12-Ⅰ评分明显降低(P<0.05)。MCI患者中,MM组MoCA评分较AD组明显升高,Cog-12-Ⅰ和Cog-12总分明显降低(P<0.05)。认知正常者中,仅Cog-12为MCI预测因素(P=0.029),在MCI患者中,Cog-12不是MCI预测因素(P=0.082)。ROC工作曲线显示,当Cog-12界值为4.5分时,预测MCI的敏感性为81.4%。结论 Cog-12是有效而全面的认知功能筛查工具,在评估患者整体智能、精神、行为的表现基础上,可有效地发现认知功能的下降,一定程度上预测将发生认知下降的可能。Objective To study the value of Cog‐12 in predicting cognitive impairment in the elder‐ly .Methods At the beginning ,56 individuals were enrolled into this study including mild cogni‐tive impairment （MCI） patients and normal cognitive function individuals‐involving a control group （n=18） ,11 patients with normal cognitive function who converted to MCI patients served as a CM group ,10 MCI patients with their MCI maintaining stable during the 2‐years follow‐up period served as MM group ,11 MCI patients who converted to AD patients served as an AD group .The patients were scored according to Cog‐12 ,MoCA and MMSE ,and their cognitive function was assessed at admission and after two years of follow‐up .Results The MoCA and MMSE scores were significantly higher whereas the Cog‐12‐Ⅰ score was significantly lower in control group than in CM group （P＆lt;0 .05） .The MoCA score was significantly higher whereas the total Cog‐12‐Ⅰ and Cog‐12 scores were significantly lower in MM group than in AD group （P＆lt;0 .05） .The Cog‐12 score was a predicting factor for MCI in patients with normal cognitive function （P=0.029） .The area under ROC curve showed that the sensitivity of Cog‐12 score in predicting MCI was 81 .4% when its cutoff value was 4 .5 .Conclusion Cog‐12 is an effective tool for assessing the intelligence ,mental state and behaviors of cognitive impairment patients and can thus predict their cognitive impairment .

关 键 词：认知障碍 阿尔茨海默病 ROC曲线 预测 

分 类 号：R749.1[医药卫生—神经病学与精神病学]