综合干预对某单位干部职工脂肪肝的疗效观察  

Observation on the effects of comprehensive intervention on the fatty liver of cadres and workers in a certain unit

作　　者：侯兵[1] 孙永军[2] 侯小玲[3] 冯曹波[1] 

机构地区：[1]第二军医大学长海医院预防保健科,上海200433 [2]海军医学研究所 [3]解放军总医院心血管内科

出　　处：《海军医学杂志》2015年第1期40-41,49,共3页Journal of Navy Medicine

摘　　要：目的探讨综合干预措施对某单位干部职工脂肪肝疗效的影响。方法对参加医院2012年度健康体检的2 247名干部职工的体检信息进行统计,比较脂肪肝组与非脂肪肝组血脂、血糖及血压情况。按数字表法随机抽取在体检中查出患有脂肪肝者200例,剔除病毒性肝炎、肝硬化、药物性肝损者20例,剩余180例进行药物治疗、健康教育和生活方式指导等综合干预24周,根据治疗前后谷草转氨酶(AST)、谷丙转氨酶(ALT)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血糖(GLU)、肝脏B超的影像变化评价疗效。结果 2 247例体检者中检出脂肪肝患者759例,检出率33.78%。脂肪肝组高血压、高TC、高TG、高GLU发病率明显高于非脂肪肝组(均P<0.01)。180例脂肪肝患者综合干预后TG、TC、LDL-C均较治疗前明显下降(P<0.05),HDL较干预前升高(P>0.05),ALT和AST异常者均恢复正常。B超显示轻度脂肪肝组中有63例消除脂肪肝,中度组中有45例转变为轻度脂肪肝,有2例消除脂肪肝;重度组中有5例转变为中度脂肪肝。结论脂肪肝与血压及血清中的TC、TG、GLU等代谢指标密切相关。以健康教育和生活方式干预为主的综合治疗对脂肪肝有良好的疗效。Objective To investigate the therapeutic effects of comprehensive intervention on the fatty liver of cadres and workers in a certain unit. Methods Health check information of 2247 cadres and workers,who underwent the 2012 health check were collected and analyzed,and then the levels of blood lipid,blood sugar and blood pressure were compared between the fatty liver group and the non-fatty liver group. Two hundred cases were randomly selected from those who were diagnosed as patients with fatty liver by ultrasonography. Twenty positive cases with virus hepatitis,hepatocirrhosis and drug-induced liver lesion were excluded from the study.The remaining 180 cases received comprehensive intervention,such as drug treatment,health and lifestyle education for 24 weeks. Both before and after treatment,therapeutic effects were assessed in accordance with changes in the levels of glutamic-oxaloacetic transaminase（ GOT）,glutamic-pyruvic transaminase（ GPT）,total cholesterol（ TC）,hyperglycemia（ TG）,high density lipoprotein-cholesterol（ HDL-C）,low density lipoprotein-cholesterol（ LDL-C）,fasting blood glucose and ultrasonography of the liver as well. Results Of the 2 247 physical examinees,759 were detected to have fatty liver,with a detecting rate of 33. 78%. The incidence rates of hypertension,TC,TG and diabetes in the fatty liver group were significantly higher than those of the non-fatty liver group（ P〈0. 01）. After comprehensive intervention,the levels of TG,TC and LDL-C in 180 people with fatty liver were significantly decreased than those before intervention（ P〈0. 05）,however,the level of HDL was increased,as compared with that before intervention（ P〉0. 05）. Those with abnormal ALT and AST all recovered to normal level,accounting for 100% .Ultrasonography revealed the following results： 63 cases in the mild fatty liver group were cured of fatty liver; 45 cases in the moderate fatty liver group were transformed into mild fatty liver,and another 2 cases were cured of fatty liver; an

关 键 词：脂肪肝 危险因素 干预 

分 类 号：R575.5[医药卫生—消化系统]