吸烟与原发性胆汁性肝硬化发病的关系研究  

Smoking and primary biliary cirrhosis:A case-control study

作　　者：陈晶[1] 贾桂[1] 高正军[1] 赵世民[1] 朱玉侠[1] 朱疆依[1] 唐亚为 时永全[1] 周新民[1] 韩者艺[1] 韩英[1] 

机构地区：[1]第四军医大学西京消化病医院,西安市710032

出　　处：《实用肝脏病杂志》2015年第2期164-167,共4页Journal of Practical Hepatology

基　　金：国家自然科学基金项目(编号:81170372/81370519);陕西省科技统筹创新工程计划(编号:2014KTCQ03-03)

摘　　要：目的探讨吸烟与原发性胆汁性肝硬化发病的关系。方法通过问卷调查收集资料,采用性别和年龄1:2配对的病例对照研究,分析2010年至2014年期间在我院住院的109例原发性胆汁性肝硬化患者和218名健康志愿者吸烟情况。结果原发性胆汁性肝硬化患者吸烟总量为(32393.8,134137.5)支,显著大于健康人组[(22356.3,104025.0)支,P<0.01];病例组开始吸烟年龄、吸烟总时间分别为(19.5±2.7)岁和(24.3±8.1)年,平均每日吸烟为(5.0,15.0)支,健康人组开始吸烟年龄、吸烟总时间分别为(23.7±6.4)岁和(23.1±9.3)年,平均每日吸烟支数为(2.5,11.3)支,差异均无统计学意义;两组间吸烟史、吸烟暴露史、开始暴露吸烟年龄、暴露吸烟总时间、平均每日暴露吸烟支数、暴露吸烟总量、主动和被动吸烟总量差异均无统计学意义。结论吸烟可能为原发性胆汁性肝硬化发病的一个重要危险因素,控制吸烟量可能是预防原发性胆汁性肝硬化发病的重要措施。Objective To investigate the causative relationship between smoking and the occurrence of pri-mary biliary cirrhosis （PBC）. Methods A questionnaire survey-based,and gender-and age-matched case-control study,was carried out. 109 patients with PBC and 218 healthy volunteers were consecutively recruited at Xijing Digestive Disease Hospital from 2009 to 2014. Results The total consumption of cigarettes in patients with PBC was remarkably higher than that in controls [（P25 32393.8,P75 134137.5） vs.（P25 22356.3,P75 104025.0）,P〈0.01];the median consumption of cigarettes in patients with PBC was also higher than that in controls （93075.0 vs. 76650.0,P〈0.01）;The age of first exposure to smoking and total lasting time of smoking in patients with PBC were （19.5±2.7） years and （24.3±8.1） years,respectively,much younger or longer than （23.7±6.4） years and （23.1 ±9.3） years in controls;the average daily consumption of cigarettes in patients with PBC were（5.0,15.0）, while they were （2.5,11.3） in controls （P〉0.05）;There existed no differences between the two groups as respect to the history of smoking or passive smoking,age of first exposure to passive smoking,total lasing time of passive smoking,the daily consumption of passive smoking and the total consumption of passive smoking,neither in the sum consumption of smoking and passive smoking. Conclusion Smoking may serve as a vital risk factor for the development of PBC.

关 键 词：原发性胆汁性肝硬化 吸烟 危险因素 剂量累积效应 

分 类 号：R575.2[医药卫生—消化系统]