颅咽管瘤囊液及脑脊液、血清hs—CRP含量测定及意义  

Detection of Hs-CRP in Hydatid Fluid, Cerebrospinal Fluid and Serum of Patients with Cranio- pharyngioma and Its Significance

作　　者：刘保国[1] 漆松涛[2] 黄广龙[2] 张龙[1] 何黎明[1] 肖罡[1] 

机构地区：[1]粤北人民医院神经外科,广东韶关512026 [2]南方医科大学南方医院神经外科,广东广州510515

出　　处：《医学临床研究》2015年第1期26-29,共4页Journal of Clinical Research

基　　金：广东省医学科研基金(项目编号A2012680)；广东省自然科学基金

摘　　要：【目的】探讨超敏C_反应蛋白（hs—CRP）在颅咽管瘤肿瘤囊液及脑脊液、血清中的含量及意义。【方法】采用透射免疫比浊法和双抗体夹心EUSA法分别测定22例造釉细胞型颅咽管瘤和6例鳞状乳头型颅咽管瘤肿瘤囊液及脑脊液、血清中hs—CRP含量，并对结果行统计学分析。【结果】造釉细胞型颅咽管瘤囊液及脑脊液、血清hs-cRP含量分别为（42．81±8．96）×105pg／mL、（0．35±0．06）×105pg／mL、（17．23±5．45）×105pg／mL，鳞状乳头型颅咽管瘤囊液及脑脊液、血清hs—cRP含量分别为（34．254±9．88）×105Pg／mL、（0．34±0．06）×105pg／mL、（16．07±9．47）×105pg／mL。颅咽管瘤囊液中hsCRP含量显著性高于脑脊液及血清中hs—CRP含量（P〈0．01），两种病理类型颅咽管瘤囊液及脑脊液、血清中hs—CRP含量相比较差异无显著性（P〉0．05）。【结论】颅咽管瘤肿瘤囊液中hs—CRP含量相对脑脊液和血清显著增高，提示囊液中炎性物质刺激可能与肿瘤组织炎症有关；不同病理类型颅咽管瘤肿瘤囊液中hs—CRP含量无显著性差异，不能以肿瘤囊液炎性程度解释不同病理类型颅咽管瘤组织炎症的差异性。[Objective]To explore the level of high-sensitivity C-reactive protein（hs-CRP） in hydatid fluid, cerebrospinal fluid（CSF） and serum of craniopharyngioma and its significance. [MethodslTurbidimetry immu- noassay and double-antibody sandwich ELISA Were used to measure the levels of hs-CRP in hydatid fluid; CSF and serum of 22 patients with ameloblast craniopharyngioma and 6 patients with squamous papillary cranio pharyngioma, respectively. The results were analyzed by statistical method. [Results]The levels of hs-CRP in hydatid fluid, CSF and serum of ameloblast craniopharyngioma were （42.81±8.96） × 105 pg/mL, （0.35± 0.06） × l0s pg/mL and （17.23±5.45） × 105 pg/mL respectively, and those in squamous papillary craniophar- yngioma were （34.25±9.88） × 105 pg/mL, （0.34±0.06） × 105 pg/mL and （16.07±9.47）×105 pg/mL re- spectively. The levels of hs-CRP in hydatid fluid of craniopbaryngioma were significantly higher than those in CSF and serum（ P 〈0.01）. There was no significant difference in hs-CRP between two pathological types of craniopharyngioma（ P 〉0.05）. [Conclusion] The significantly higher level of hs-CRP in hydatid fluid of cra- niopharyngioma than that in cerebrospinal fluid and serum suggests that stimulation by inflammation sub- stances in hydatid fluid may be related to the tumor tissue inflammation. There is no significant difference in hs-CRP level of hydatid fluid among different pathological types of craniopharyngioma. It indicates that the in- flammatory severity in tumor hydatid fluid can not explain the diversity of craniopharyngioma tissue inflamma- tion with different pathological types.

关 键 词：颅咽管瘤/病理学 C反应蛋白质/代谢 血液 脑脊髓液 

分 类 号：R739.41[医药卫生—肿瘤]