西妥昔单抗联合不同化疗方案治疗晚期直肠癌的疗效观察  

Efficacies of Treating Advanced Colorectal Cancer with Cetuximab Plus Different Chemotherapy Regimens

作　　者：丁万宝[1] 张培先[1] 石岚[1] 龙轶[1] 张洁[1] 李岩[1] 邓磊[1] 杜鸿昱[1] 宋琳婧[1] 袁克华[1] 

机构地区：[1]云南省昆明市延安医院,云南 昆明650051

出　　处：《医学临床研究》2015年第1期77-79,共3页Journal of Clinical Research

摘　　要：目的观察西妥昔单抗分别联合FOLFOX与FOLFIRI两种化疗方案治疗晚期直肠癌患者的临床疗效和毒副反应。方法将80例晚期直肠癌患者随机分为A、B两组，每组各40例；A组：使用西妥昔单抗联合FOLFOX化疗方案治疗，B组：使用西妥昔单抗联合FOLFIRI化疗方案治疗。治疗6周后观察比较两组患者的近期疗效、生活质量和不良反应。结果 A、B两组患者的有效率和生活质量改善率比较差异无显著性（P ＞0．05）；两组患者的肿瘤直径和厚度均较治疗前明显减小（P ＜0．05），但两组之间比较差异无显著性（P ＞0．05）；两组不良发应在腹泻、神经毒性的发生上差异有统计学意义（P ＜0．05）。结论西妥昔单抗分别联合FOLFOX与FOLFIRI两种方案治疗晚期直肠癌疗效相当，但在不良反应方面前者以神经毒性反应多见，后者以腹泻多见，总发生率两者相当。[Objective] To explore the clinical efficacies and adverse reactions of cetuximab plus FOLFOX or FOLFIRI chemotherapy in the treatment of advanced colorectal cancer .[Methods] A total of 80 patients with advanced colorectal cancer patients were randomly divided into A and B groups （ n=40 each） .Group A received cetuximab plus FOLFOX regimen while group B cetuximab plus FOLFIRI chemotherapy .And their immediate outcomes ,quality of life and adverse reactions after 6 weeks were recorded and compared .[Re‐sults] There were insignificant inter‐group differences in efficiency or life quality improvement rate （ P〉0 .05） .For both groups ,the diameter and thickness of tumor significantly decreased as compared with pre‐treatment （ P 〈0 .05） .But the inter‐group difference was insignificant （ P〉0 .05） .Occurrences of diarrhea and neurotoxicity had significant inter‐group differences （ P 〈0 .05） .[Conclusion]Cetuximab plus FOLFOX or FOLFIRI has similar efficacies for advanced colorectal cancer .Only individual differences exist in adverse reactions .

关 键 词：抗体 单克隆/治疗应用 抗肿瘤药/治疗应用 直肠肿瘤/药物疗法 抗肿瘤联合化疗方案 

分 类 号：R735.37[医药卫生—肿瘤]