骨髓源性细胞在雌激素调节肿瘤血管新生中的作用及其应用  

Roles of bone marrow-derived cells in tumor angiogenesis mediated by estrogen and the application in drug discovery

作　　者：禚映辰 陈敬国[1] 李雪倩[1] 郑巧伟[1] 赵雪[1] 马文兵[1] 赵培培[1] 封卫毅[1] 

机构地区：[1]西安交通大学第一附属医院,西安710061

出　　处：《中国新药杂志》2015年第5期533-539,共7页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81071765;81372379)

摘　　要：实体肿瘤的发生发展过程离不开血管新生。骨髓源性细胞(Bone marrow-derived cells,BMDCs)在肿瘤血管新生的过程中发挥十分重要的作用,其中表达雌激素受体阳性的BMDCs受到雌激素调节。雌激素又与多种女性常见肿瘤的发生发展过程密切相关,分析表明肿瘤血管新生、BMDCs、雌激素三者之间存在紧密联系。在肿瘤治疗过程中,BMDCs可作为肿瘤治疗的新靶点和药物载体,为肿瘤的治疗开辟新道路。Angiogenesis is a crucial step in the growth and metastasis of cancer. Bone marrow-derived cells（ BMDCs） play a central role in the process of tumor growth and angiogenesis,especially estrogen receptor-positive BMDCs. Moreover,long-term estrogen exposure is closely associated with poor overall survival of patients with estrogen-dependent tumor. Hence,there are close relationships among BMDCs,tumor angiogenesis and estrogen. As a new target and drug carrier,BMDCs have paved a new road in the therapy of cancer.

关 键 词：骨髓源性细胞 肿瘤血管新生 雌激素 肿瘤治疗 新药研究 

分 类 号：R730.58[医药卫生—肿瘤]