盐酸氯普鲁卡因的合成  

Synthesis of Chloroprocaine Hydrochloride

作　　者：王卫芳 王丽娅 胡璞 

机构地区：[1]浙江仙琚制药股份有限公司,浙江仙居317300

出　　处：《中国现代应用药学》2015年第3期304-306,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的合成盐酸氯普鲁卡因并改进工艺。方法以2-氯-4-硝基苯甲酸为起始物料,经过还原、酯化、成盐3步反应制得盐酸氯普鲁卡因。结果目标物经IR、1H-NMR、13C-NMR和MS确证结构,反应总收率达到73.9%,纯度为99.76%。结论该合成路线操作简便、反应条件温和,适于工业化生产。OBJECTIVE To synthesis chloroprocainehydrochloride and optimize the reaction conditions.METHODSThe chloroprocainehydrochloride was synthesized from 2-chloro-4-nitrobenzoic acid via reduction,esterification and salification.RESULTS The structure of product was identified by IR,1H-NMR,13C-NMR and MS,the total yield was 73.9% and the HPLC purity was 99.76%.CONCLUSION The synthetic process is simple,easy to control and suitable for industrial production.

关 键 词：氯普鲁卡因 2-氯-4-硝基苯甲酸 合成 

分 类 号：R914.4[医药卫生—药物化学]