应用光学相干断层扫描仪定量检测50岁以上老年人视盘周围视网膜神经纤维层厚度的研究  

Quantitative measurement of retinal nerve fiber layer thickness by using optical coherence tomography in people over 50 years old

作　　者：孙冉[1] 张健[1] 刘大川[1] 方薇[1] 杨惠清[1] 赵丽燕[1] 赵立萍[1] 陈瑞婧 唐一杰[2] 

机构地区：[1]首都医科大学宣武医院眼科,北京100053 [2]华北电网有限公司北京电力医院呼吸科,北京100073

出　　处：《中国现代医学杂志》2015年第5期66-69,共4页China Journal of Modern Medicine

基　　金：北京市委组织部优秀人才资助项目(No:20051D0501821)

摘　　要：目的通过光学相干断层扫描仪（OCT）定量测量50岁以上老年人视盘周围视网膜神经纤维层（RNFL）厚度,研究老年人盘周RNFL厚度特点。方法应用OCT分别定量测量观察组（50岁以上老年人120例,196只眼）和对照组（20~50岁中青年人108例,193只眼）视盘全周、上方、下方、鼻侧、颞侧5个区域的RNFL厚度,应用独立样本t检验比较两组视盘全周和各象限RNFL厚度的差异性。结果观察组视盘全周、上方、下方、鼻侧、颞侧象限RNFL厚度分别为（98.68±14.25）、（125.56±13.87）、（128.04±12.63）、（73.61±13.36）和（67.53±13.87）μm,对照组视盘全周、上方、下方、鼻侧、颞侧象限RNFL厚度分别为（109.02±14.17）、（143.89±13.41）、（133.04±11.72）、（86.61±14.33）和（72.53±12.03）μm,观察组视盘全周、上方象限、鼻侧象限RNFL厚度较对照组差异有统计学意义上的变薄（P〈0.05）,两组下方象限、颞侧象限RNFL厚度差异无统计学意义（P〉0.05）。结论 50岁以上老年人较低年龄人群盘周RNFL厚度变薄,主要表现为上方和鼻侧象限RNFL厚度变薄。【Objective】 To study the characteristics of the peripapillary retinal nerve fiber layer（RNFL）thickness in the people over 50 years old by using optical coherence tomography（OCT）.【Methods】 The study objects were divided into observation group（120 cases of people over 50 years old, 196 eyes） and control group（108 cases of 20 ~ 50 years old people, 193 eyes）. OCT was used to quantitatively measure the overall mean peripapillary RNFL thickness and different quadrants’ RNFL thickness（superior, inferior, nasal, temporal quadrant）. The differences of the overall mean peripapillary RNFL thickness and each quadrant RNFL thickness between the two groups were observed using independent samples t test. 【Results】 In the observation group, the overall mean peripapillary RNFL thickness was（98.68 ± 14.25） μm, the superior quadrant one was（125.56 ± 13.87） μm, the inferior quadrant one was（128.04 ± 12.63） μm, the nasal quadrant one was（73.61 ± 13.36） μm, the temporal quadrant one was（67.53 ± 13.87） μm. In the control group, the overall mean RNFL thickness was（109.02 ± 14.17） μm, the superior quadrant one was（143.89 ± 13.41） μm, the inferior quadrant was（133.04 ± 11.72） μm, the nasal quadrant was（86.61 ± 14.33） μm, the temporal quadrant was（72.53 ± 12.03） μm. In the observation group, the overall mean RNFL thickness, the superior and nasal quadrant RNFL thickness were statistically thinner than those in the control group（P 〈0.05）, but RNFL thickness in other quadrants of both groups had no statistic difference（P 〉0.05）. 【Conclusion】 The overall mean peripapillary RNFL thickness in the people over 50 years old is thinner than that in the low age crowd, especially in the superior and nasal quadrants.

关 键 词：光学相干断层扫描 视神经 视网膜神经纤维层 病理学 

分 类 号：R774[医药卫生—眼科]