瑞波西汀与帕罗西汀治疗抑郁症疗效比较  

Comparative study of reboxetine and paroxetineinthe in the treatment of depression

作　　者：赵路平[1] 

机构地区：[1]沈阳市精神卫生中心4病房,110168

出　　处：《世界睡眠医学杂志》2014年第5期284-286,共3页World Journal of Sleep Medicine

摘　　要：目的比较瑞波西汀与帕罗西汀治疗抑郁症的疗效和安全性。方法将84例抑郁症患者按照随机数字表随机分为2组各42例,瑞波西汀组给予瑞波西汀,初始剂量4 mg/d,2周内渐增至12 mg/d;帕罗西汀组给予帕罗西汀,初始剂量20 mg/d,2周内渐增至50 mg/d,疗程均为6周。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,不良反应量表(TESS)评定不良反应。结果瑞波西汀组有效率为88.0%、显效率为76.1%;帕罗西汀组有效率为90.4%、显效率为78.5%,2组显效率比较差异无统计学意义(P>0.05)。结论瑞波西汀与帕罗西汀治疗抑郁症均有疗,依从性好,且瑞波西汀起效较帕罗西汀快。Objective To compare the clinical efficacy and safety of of reboxetine vs. paroxet ine in the treatment of depression. Methods 84 patients w ere randomly divided into reboxe tine（ n = 42） and paroxetine（ n = 42） group for 6 weeks.The efficacy and side effects w ere assessed with the Hamilton Depression Rating Scale（ HAM D） and Treatment Emergent Symptom Scale（ TESS）,respectively. Results The total efficiency in reboxetine group and paroxetineinthe group were 88.0% and 90.4% respectively,and no significant difference between two groups（ P 0.05）. Conclusion Both reboxetine and paroxetine have evident effects,higher safety and better compliance in the treatment of depression,but the former shows a faster effect.

关 键 词：瑞波西汀 帕罗西汀 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]