口腔念珠菌病的菌群分布特点及体外抗真菌药敏试验研究  

Oral candidiasis flora distribution and antifungal susceptibility test in vitro studies

作　　者：张华[1] 董培[2] 

机构地区：[1]天津医科大学口腔医院检验科,天津300070 [2]天津医科大学口腔医院药剂科,天津300070

出　　处：《全科口腔医学电子杂志》2014年第10期35-36,共2页Electronic Journal of General Stomatology

摘　　要：目的探讨分析口腔念珠菌病的菌群分布特点,研究体外抗真菌药敏试验。方法随机抽取口腔念珠菌病患者85例,分离菌株,并采用显色培养基培养,鉴定分离株的菌群分布特点;进行体外抗真菌药敏试验,检测念珠菌对氟康唑和伊曲康唑的敏感性。结果氟康唑对白色念珠菌的敏感率(66.7%)显著高于伊曲康唑对白色念珠菌的敏感率(39.4%),组间比较差异有统计学意义(x2=8.724,P=0.016,P<0.05)。结论口腔念珠菌以白色念珠菌最多,并有一定的耐药现象,白色假丝酵母菌对氟康唑敏感性好。Objective Analyzes the bacterial flora distribution characteristics of oral candidiasis, study in vitro antifungal susceptibility test. Methods A random sample of oral candida patients 85 cases, isolates, and USES the chromogenic medium, identification of bacterial flora distribution characteristics of isolates; In vitro antifungal susceptibility test, detection of candida sensitivity to fluconazole and itraconazole. Results Of candida albicans fluconazole sensitive rate was （66.7%）, significantly higher than that of itraconazole sensitive rate of candida albicans （39.4%）, and compare the differences between groups was statistically significant （χ2= 8.724, P = 0.016, P〈0.05）.Conclusion Oral candida albicans candida as most, and has certain resistance phenomenon, white candida to fluconazole, sensitivity is good.

关 键 词：口腔念珠菌 菌群分布 抗真菌药敏试验 氟康唑 伊曲康唑 

分 类 号：R781.5[医药卫生—口腔医学]