静脉血栓栓塞症的免疫功能变化  

The change of immune function occurring in the process of venous thromboembolism

作　　者：曾金美 周琳[1] 宋浩明[1] 

机构地区：[1]同济大学附属同济医院心内科,上海200065

出　　处：《外科研究与新技术》2014年第4期279-282,294,共5页Surgical Research and New Technique

基　　金：上海市科委重点项目课题(11411951400);上海市卫生局课题(2010108)

摘　　要：静脉血栓栓塞症(VTE)是临床上常见病、多发病,但却容易误诊、漏诊。近一个多世纪来经典的Virchow血栓形成三要素学说(血流缓慢、凝血功能亢进和血管壁损伤)一直占据着血栓性疾病发病机制的主导地位,然而随着医疗技术的不断进步以及各国学者的不断探索,我们发现VTE的发病机制远远没有那么简单,而免疫炎症反应在VTE的发生过程中扮演了极为重要的角色。文中从细胞水平、分子水平就静脉血栓栓塞症发生过程中的免疫功能变化作一综述。Venous thromboembolism （VTE） is a clinical common and frequently-occurring disease,but it is easy to make misdiagnosis and missed diagnosis. In the past century,Virchow,s theory“The three elements of thrombosis”（slow coronary flow,hyperfunction of coagulation system,and injury of vascular wall ） has been occupying the dominant position to the pathogenesis of thrombotic diseases. However,with the advance of medical technology,and constantly exploring of various countries＇ scholars,we found that the pathogenesis of VTE is far from simple,In addition, the inflammatory immune response plays an extremely important role in the process of the occurrence of VTE. In this paper,the change of immune function occurring in the process of venous thromboembolism at the cellular level and molecular level is reviewed.

关 键 词：静脉血栓栓塞症 免疫功能 细胞水平 分子水平 

分 类 号：R543.6[医药卫生—心血管疾病]