两种以甲状腺全切为基础治疗方案用于cN0甲状腺乳头状癌患者临床对比研究  

Clinical comparative study of two kinds of treatment schemes based on total thyroidectomy for patients with c N0papillary thyroid cancer

作　　者：赵强[1] 姜世平[1] 冯树森[1] 

机构地区：[1]四川省雅安市人民医院普外科,四川雅安625000

出　　处：《中国现代医学杂志》2015年第7期96-99,共4页China Journal of Modern Medicine

摘　　要：目的探讨术后131I与术中中央区淋巴结清扫分别联合甲状腺全切除治疗c N0甲状腺乳头状癌临床效果的差异。方法选取该院近年来收治甲状腺乳头状癌c N0患者160例,采用随机数字表法分为A组(80例)和B组(80例);其中A组患者采用甲状腺全切除+术后131I治疗;B组患者则采用甲状腺全切除+术中中央区淋巴结清扫治疗;比较两组患者术后随访及并发症发生情况等。结果 B组患者中央区复发率,颈侧区转移率及无影像学证据TG升高率均显著低于A组,差异有统计学意义(P<0.05);两组患者甲状旁腺功能低下,喉返神经损伤及喉上神经损伤等并发症发生率比较差异无统计学意义(P>0.05)。结论与术后131I辅助治疗相比,中央区淋巴结清扫联合甲状腺全切除治疗c N0甲状腺乳头状癌能够有效降低远期复发转移率,且未增加术后并发症发生风险,可作为临床首选治疗手段。【Objective】To investigate clinical effect of ^131I and central lymph node dissection assisted with thyroidectomy on patients with cN0 papillary thyroid carcinoma. 【Methods】160 patients with cN0 papillary thyroid carcinoma were chosen in recent years in our hospital and randomly divided into two groups including A group（80patients） with ^131I after surgery assisted with thyroidectomy and B group（80 patients） with central lymph node dissection assisted with thyroidectomy; and the follow-up occurrence and complication incidence after surgery of both groups were compared. 【Results】The central lateral neck recurrence rate, metastasis rate and TG increase rate without radiographic evidence of B group was significant better than A group（P〈0.05）. There was no significant difference in complication incidence including hypoparathyroidism, injury of recurrent laryngeal nerve and superior laryngeal nerve between the two groups（P〈0.05）. 【Conclusion】Compared with ^131I after surgery assisted treatment,central lymph node dissection assisted with thyroidectomy on patients with cN0 papillary thyroid carcinoma can efficiently reduce the incidence of recurrence and metastasis without higher complication risk as the first choice of clinical treatment method.

关 键 词：^131I 中央区淋巴结清扫 甲状腺全切除 CN0 甲状腺乳头状癌 

分 类 号：R736.1[医药卫生—肿瘤]