环孢素A口服溶液不同给药剂量对注射器内残留量的影响  

Effect of Cyclosporin A Oral Solution with Different Dosing on the Syringe Residue

作　　者：魏婷[1] 张欣[1] 许俊羽[1] 盛晓燕[1] 钟旭辉[1] 周颖[1] 崔一民[1] 

机构地区：[1]北京大学第一医院药剂科,北京100034

出　　处：《中国药房》2015年第9期1182-1184,共3页China Pharmacy

摘　　要：目的:考察环孢素A口服溶液不同给药剂量对一次性注射器内残留量的影响。方法:将40支一次性无菌注射器均分为0.9%氯化钠注射液组和环孢素A口服溶液组,两组又均分为4个亚组。分别测定两组注射器内溶液的残留量,并计算残留百分比。结果:环孢素A口服溶液组各亚组一次性无菌注射器内环孢素A的残留百分比均显著高于0.9%氯化钠注射液组,差异有统计学意义(P<0.05)。环孢素A口服溶液各亚组间除0.5 ml组与0.8 ml组间比较差异无统计学意义(P>0.05)外,其他各组间比较差异均有统计学意义(P<0.05)。结论:儿童采用一次性无菌注射器口服给予环孢素A时抽取的剂量越小,注射器内药物的残留百分比越大;当注射器抽取环孢素A溶液剂量在0.1 ml时,注射器内药物的残留量百分比最高。OBJECTIVE： To explore the effect of Cyclosporin A oral solution with different dosing on the syringe residue. METHODS：A total of 40 disposable sterile syringes were divided into 0.9% sodium chloride injection group and cyclosporin A oral solution group. The residues of cyclosporin A in syringe were determined and the percentage of residues was calculated. RESULTS ： The proportion of residues in disposable sterile syringes in cyclosporin A oral solution group was significantly higher than 0.9% so- dium chloride injection group, with significant difference（P〈0.05）. There were significant differences among the subgroups of cy- closporin A oral solution group （P〈0.05） except for 0.5 ml group and 0.8 ml group （P〉0.05）. CONCLUSIONS： When children were orally given cyclosporin A by disposable sterile syringes, the proportion of resides in syringes was greater when the extract dosage of cyclosporin A was smaller. The proportion was the highest when the dosage of cyclosporin A solution was 0.1 ml.

关 键 词：环孢素A 儿童 注射器 残留量 

分 类 号：R979.5[医药卫生—药品]