乙肝病毒X蛋白结合蛋白过表达在乳腺癌诊断及预后评估中的意义  

The role of HBXIP overexpression in the prognostic evaluation of breast cancer

作　　者：张华敏[1,2] 李楠[1,2] 孙洁[1,2] 刘双萍[1,2] 

机构地区：[1]延边大学医学院病理学教研室 [2]延边大学长白山天然资源与功能分子省部共建教育部重点实验室,133002

出　　处：《实用医学杂志》2015年第5期737-740,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:31301065);吉林省科技厅青年基金项目(编号:20130522010JH)

摘　　要：目的:探讨乙肝病毒X蛋白结合蛋白(HBXIP)在乳腺癌组织中的表达及预后评估的临床病理学意义。方法:采用免疫组化En Vision法检测60例乳腺癌、15例乳腺导管内原位癌(ductal carcinoma in situ,DCIS)及27例癌旁正常乳腺组织中HBXIP蛋白的表达,并结合临床病理指标及生存时间进行统计学分析。结果:乳腺肿瘤组织中HBXIP蛋白阳性表达率为88.3%(53/60),明显高于乳腺导管内原位癌组织和癌旁正常乳腺组织(分别为46.7%和29.6%,均P<0.01);卡方检验结果显示,HBXIP蛋白表达与乳腺癌患者临床分期、淋巴结转移及HER-2表达密切相关(P值分别为0.003、0.027和0.009),而与性别、原发灶大小、临床分级、ER及PR表达等参数无关。结论:HBXIP蛋白过表达可以预示乳腺癌患者的不良预后,而且可以作为早期诊断的重要辅助指标和乳腺癌分子靶向治疗的新候选基因靶点。Objective To investigate the role of HBXIP overexpression in the prognostic evaluation of breast cancer. Methods HBXIP expression was detected in the tissues of 60 breast cancer cases and 15 cases of ductal cancer in situ （DCIS） as well as in the adjacent non-tumorous tissues of 27 cases of breast cancer using EnVision immunohistochemical staining method. The correlations between the HBXIP overexpressions and the clinical pathological characters of the patients with breast cancer were also analyzed. Results The HBXIP proteins showed a major cytoplasmic staining pattern in breast cancer. The strongly positive rate of HBXIP was75.0%（45/60） in breast cancer, significantly higher than in DCIS （20.0%, 3/15） and adjacent non-tumorous tissues （14.8%, 4/27）. High-level expression of HBXIP was correlated with late clinical stage, lymph node metastasis and HER-2 positive expression in breast cancer. Conclusions The expression level of HBXIP is closely related to the progression and prognosis of breast cancer. It might be a potential biomarker and therapeutic target of breast cancer.

关 键 词：乳腺肿瘤 HBXIP 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]