静脉窦血栓患者血管内皮生长因子水平与预后的关系  

The relationship between plasma levels of vascular endothelial growth factor and prognosis in patients with cerebral venous sinus thrombosis

作　　者：温清[1] 刘人恺[1] 杨春水[1] 

机构地区：[1]广东医学院附属南山医院神经内科,深圳518052

出　　处：《中国实用神经疾病杂志》2015年第4期41-42,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)在静脉窦血栓患者中的表达水平及其与近期预后的关系。方法采用ELISA法检测静脉窦血栓患者(84例)和健康对照人群(70例)血浆VEGF水平,随访12个月评估静脉窦血栓患者不良终点事件发生情况。结果静脉窦血栓患者血浆VEGF水平较正常对照组明显升高[(195.15±24.62)μg/mL vs.(165.66±20.60)μg/mL(P<0.01)]。随访结束后,高VEGF组(31例,VEGF≥200μg/mL)发生不良事件12例,低VEGF组(53例,VEGF<200μg/mL)发生不良事件11例,Kaplan-Meier生存曲线显示2组差异有统计学意义(P=0.03)。另外,不良终点事件发生者(23例)血浆VEGF水平较无不良终点事件发生者(51例)明显增高(P<0.01)。结论静脉窦血栓形成可诱导VEGF表达增强,VEGF水平升高越明显近期预后越差,可能与血管源性脑水肿有关。Objective To investigate the relationship between plasma levels of vascular endothelial growth factor（VEGF）and prognosis in patients with cerebral venous sinus thrombosis（CVST）.Methods The plasma VEGF levels of 84 patients with CVST and 70 healthy people were detected with ELISA,and then the short-term major adverse events（MAE）of patients were observed after followed up for 12 months.Results The plasma VEFG level of patients with CVST was higher than that of control group[（195.15±24.62）μg/mL vs.（165.66±20.60）μg/mL].The occurrence rate of high VEGF group was higher than that of lower VEGF group.Conclusion Cerebral venous sinus thrombosis can induce the enhanced expression of VEGF,and the more the VEGF expression is,the worse the prognosis is.

关 键 词：静脉窦血栓 血管内皮生长因子 预后 

分 类 号：R743.32[医药卫生—神经病学与精神病学]