髓系来源抑制细胞与肝脏疾病  

Myeloid Derived Suppressor Cells and Liver Diseases

作　　者：徐跃元 向晓星 

机构地区：[1]扬州大学临床医学院苏北人民医院消化内科307病区,江苏扬州225001

出　　处：《医学综述》2015年第2期216-218,共3页Medical Recapitulate

摘　　要：髓系来源抑制细胞(MDSC)是一群异质性细胞,其免疫抑制功能的重要性首先在肿瘤患者和荷瘤小鼠的研究中被提出。近年研究显示,MDSC和许多非肿瘤性疾病的发生、发展有关。MDSC可通过多种机制调节天然免疫和适应性免疫,其数量的改变常与肿瘤负荷、远处转移、分期和患者的预后密切相关。MDSC在肝细胞癌、病毒性肝炎、自身免疫性肝炎发病机制中作用的研究对阐述MDSC在肝脏疾病发生、发展及预后中的作用具有重要意义。Myeloid derived suppressor cells（ MDSC） represent a heterogenous population of cells. The importance of the suppressive function of MDSC was first suggested by studies involving cancer patients and cancerbearing mice. In addition,recent studies have demonstrated that MDSC can also be involved in many other pathological conditions. MDSC can modulate innate and adaptive immune responses through a variety of mechanisms.The number of MDSC is closely related with tumor burden,remote metastasis,tumor stage and prognosis. Research about MDSC function in the pathogenesis of hepatocellular carcinoma,viral hepatitis and autoimmune hepatitis is of great importance to elaborate the role of MDSC in the development and prognosis of liver diseases.

关 键 词：髓系来源抑制细胞 免疫抑制 肝脏疾病 发病机制 预后 

分 类 号：R735.7[医药卫生—肿瘤] R512.6[医药卫生—临床医学]