脂联素转录和翻译机制的研究进展  

Recent Progress of Adiponectin in the Regulation of Gene Transcription and Translation

作　　者：孙文君[1] 胡浩[1] 袁国跃[1] 

机构地区：[1]江苏大学附属医院内分泌科,江苏镇江212000

出　　处：《医学综述》2015年第5期769-771,共3页Medical Recapitulate

基　　金：国家自然科学基金面上项目(81370965);江苏省自然科学基金(BK2009208);江苏省卫生厅国际交流支撑计划及面上科技项目(H201247);镇江市科技支撑-社会发展项目(SH2012027)

摘　　要：脂联素是由脂肪细胞分泌的脂肪因子,在胰岛素抵抗、抗动脉粥样硬化和抗炎症方面都发挥了重要的作用。在血液循环中脂联素以三聚体、六聚体和高分子量多聚体3种形式存在,不同的聚化物形式在调控能量平衡方面的作用不同。调控脂联素转录、翻译、多聚化和分泌的相关机制研究可为治疗胰岛素抵抗、2型糖尿病和与肥胖相关的其他代谢疾病提供新的治疗靶点。Adiponectin is derived from adipose tissue , and plays an increasingly important role in antidi-abetic,anti-atherogenic and anti-inflammatory process.There are three species circulating in the bloodstream：trimeric,hexameric and high-molecular-weight polymer.Different forms of adiponectin have different functions in the regulation of energy homoeostasis.The studies on the mechanisms regulating adiponectin gene tran-scription,multimerization and secretion may provide new therapeutic targets for for the treatment of insulin resistance,type 2 diabetes and other obesity-related metabolic disorders.

关 键 词：脂联素 转录 翻译 多聚化 分泌 

分 类 号：R34[医药卫生—基础医学]