肺炎衣原体感染和老年急性脑梗死患者血脂及C反应蛋白的关系研究  

Study on relationship between Chlamydia pneumoniae infecton, serum levels of lipid and C-reaction protein in senile patients with acute cerebral infarction

作　　者：刘红[1] 赵敏[1] 刘一宁[1] 夏章勇[1] 曲怀谦[1] 

机构地区：[1]聊城市人民医院神经内科山东省心脑血管病微创治疗工程技术研究中心,山东省252000

出　　处：《中华临床医师杂志（电子版）》2015年第5期29-32,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金："十二五"国家科技支撑计划课题(2011BAI08B02)

摘　　要：目的通过对肺炎衣原体抗体水平、血脂及C反应蛋白(CRP)的观察,探讨肺炎衣原体感染与老年急性脑梗死的相关性。方法选取2013年3月至2014年3月住院的老年急性脑梗死患者65例作为研究组,以同时期健康体检者65人作为对照组,检测其血清肺炎衣原体特异性抗体Ig A、Ig M、Ig G及血脂(TC、LDL、TG、HDL)和CRP。结果研究组Ig A、Ig G抗体阳性率和慢性感染率均显著高于对照组,而Ig M抗体阳性率和急性感染率两组间无显著性差异(P>0.05);研究组TC、LDL、TG及CRP水平均显著高于对照组,HDL水平则显著低于对照组(P<0.01);研究组感染病例血脂及CPR水平与未感染病例差异性显著(P均<0.05),具有统计学意义;Ig A、Ig G抗体阳性为老年急性脑梗死独立危险因素,Ig M抗体阳性与之无相关性。结论肺炎衣原体慢性感染与老年急性脑梗死相关,肺炎衣原体可能通过血脂代谢异常及炎症反应参与急性脑梗死的病变过程。ObjectiveTo investigate the relationship between Chlamydia pneumoniae infecton and serum levels of lipid and C-reaction protein in senile patients with acute cerebral infarction.MethodsSixty-five senile patients with acute cerebral infarction who were hospitalized from March, 2013 to March, 2014 were selected as the study group, while sixty-five healthy volunteers during the same period were set as the control group. The specific IgA, IgM, IgG of Chlamydia pneumoniae, the blood lipids （TC, LDL, TG and HDL） and C-reactive protein of two groups were detected and compared respectively.ResultsThe IgA, IgG antibody positive rate and chronic infection of study group were significantly higher than control group, while IgM positive rate and acute infection of two groups had no significant difference （P〉0.05）. TC, LDL, TG and C-reaction protein levels of study group were significantly higher and HDL levels were significantly lower than the control group （P〈0.01）; blood lipid levels and C-reaction protein of infections cases in the study group were significantly higher than uninfected patients （P〈0.05）. IgA, IgG antibodies were independent risk factor for acute cerebral infarction, but IgM antibody positive had no correlation with acute cerebral infarction.ConclusionChronic chlamydia pneumoniae infection has a close correlation with senile acute cerebral infarction. Chlamydia pneumoniae may involved in the pathological process of acute cerebral infarction by causing inflammation damage and abnormal lipid metabolism .

关 键 词：脑梗死 衣原体 肺炎 脂类 C反应蛋白质 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R563.1[医药卫生—临床医学]